Pub. Date:
Birkh�user Boston
Gene Therapeutics: Methods and Applications of Direct Gene Transfer

Gene Therapeutics: Methods and Applications of Direct Gene Transfer

by J.F. Crow, Jon A. Wolff


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Product Details

ISBN-13: 9781468468243
Publisher: Birkh�user Boston
Publication date: 02/26/2012
Edition description: Softcover reprint of the original 1st ed. 1994
Pages: 417
Product dimensions: 6.10(w) x 9.25(h) x 0.04(d)

Table of Contents

I Background.- A History of Gene Transfer and Therapy.- Producing Mouse Genetic Models for Human Diseases.- Post-Transcriptional Considerations of Gene Expression: Translation, MRNA Stability, and Poly(A) Processing.- Promoters, Enhancers, and Inducible Elements for Gene Therapy.- II Methods and Mechanisms.- Possible Mechanisms of DNA Uptake in Skeletal Muscle.- Receptor-Mediated Gene Delivery Employing Adenovirus-Polylysine-DNA Complexes.- Gene Transfer in Mammalian Cells Using Liposomes as Carriers.- In Vivo Gene Therapy via Receptor-Mediated DNA Delivery.- Calcium Phosphate-Mediated DNA Transfection.- Cellular Internalization of Oligodeoxynucleotides.- Gene Transfer via Particle Bombardment: Applications of the Accell Gene Gun.- Electrically-Induced DNA Transfer Into Cells. Electrotransfection In Vivo.- III Applications.- Pharmacokinetic Considerations in the Use of Genes as Pharmaceuticals.- Virus-Mediated Genetic Treatment of Rodent Gliomas.- Gene Therapy for Adenosine Deaminase Deficiency and Malignant Solid Tumors.- Development of Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous System.- Direct Gene Transfer and Catheter Based Gene Delivery Systems: Applications to Cardiovascular Diseases and Malignancy.- Gene Therapy for Arthritis.- Gene Therapy: The Advent of Adenovirus.- In Vivo Gene Transfer Into the Heart.- Receptor-Mediated Targeted Gene Delivery Using Asialoglycoprotein-Polylysine Conjugates.- Retroviral-Mediated Gene Transfer and Duchenne Muscular Dystrophy.- Keyword Index.

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