Genetic Damage in Human Spermatozoa

by Elisabetta Baldi (Editor), Monica Muratori (Editor)

Overview

There are several types of damage that can be found in the male gamete. Genetic damage in spermatozoa can originate during spermatogenesis, or it can originate during transit in both male and female genital tracts. Damage can also be due to ageing, environmental or iatrogenic conditions, as well as to the prools to cryopreserve and to select spermatozoa in assisted reproduction techniques. The purpose of this book is to provide a comprehensive resource for all possible DNA damages in sperm, the relation to fertility and infertility, and possible transgenerational heritable effects.

Product Details

ISBN-13:	9781489994714
Publisher:	Springer New York
Publication date:	09/29/2015
Series:	Advances in Experimental Medicine and Biology , #791
Edition description:	Softcover reprint of the original 1st ed. 2014
Pages:	195
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

About the Author

Dr. Baldi started to work in sperm biology in 1990, by studying several aspect of sperm functions as well as DNA damage. She published 155 publications in IF journals with peer review. She has been invited as speaker in many National and International Congresses and Symposia. She is currently associate professor of Clinical Pathology at the University of Florence and responsible of the Laboratory of semen analysis and semen cryopreservation of the Azienda Ospedaliera-Universitaria Careggi

Dr. Muratori started to work in sperm biology in 1997, by mainly studying sperm DNA damage. She published 80 publications with IF journals with peer review. She has been invited as speaker in many National and International Congresses and Symposia. She is currently researcher of Applied Technical and Medical Sciences at the University of Florence

Table of Contents

Structure of chromatin in spermatozoa.- Genomic changes in spermatozoa of aging male.- Chromosomal aberrations and aneuploidies.- The sperm epigenome: implications for the embryo.- Paternal reprogramming of genome: transgenerational effects.- Alterations in protamination.- Sperm DNA fragmentation and base oxidation.- Iatrogenic Genetic damage.- Sperm selection: effect on sperm DNA quality.- Effect of antioxidant treatments on sperm genetic damage.- Index.