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Overview

A comprehensive review of research examining intermediary mechanisms to understand the link between genetic variation and addiction liability.

Although there is scientific consensus that genetic factors play a substantial role in an individual's vulnerability to drug or alcohol addiction, specific genetic variables linked to risk or resilience remain elusive. Understanding how genetic factors contribute to addiction may require focusing on intermediary mechanisms, or intermediate phenotypes, that connect genetic variation and risk for addiction. This book offers a comprehensive review of this mechanistic-centered approach and the most promising intermediate phenotypes identified in empirical research.

The contributors first consider the most established findings in the field, including variability in drug metabolism, brain electrophysiological profiles, and subjective reactions to direct drug effects; they go on to review highly promising areas such as expectancies, attentional processing, and behavioral economic variables; and finally, they investigate more exploratory approaches, including the differential susceptibility hypothesis and epigenetic modifications. Taken together, the chapters offer a macro-level testing of the hypothesis that these alternative, mechanistic phenotypes can advance the understanding of genetic influences on addiction. The book will be of interest to researchers and practitioners in a range of disciplines, including behavioral genetics, psychology, pharmacology, neuroscience, and sociology.

Contributors
John Acker, Steven R. H. Beach, Gene H. Brody, Angela D. Bryan, Megan J. Chenoweth, Danielle M. Dick, Eske D. Derks, Mary-Anne Enoch, Meg Gerrard, Frederick X. Gibbons, Thomas E. Gladwin, Mark S. Goldman, Marcus Heilig, Kent E. Hutchison, Hollis C. Karoly, Steven M. Kogan, Man Kit Lei, Susan Luczak, James MacKillop, Renee E. Magnan, Leah M. Mayo, Marcus R. Munafò, Daria Orlowska, Abraham A. Palmer, Danielle Pandika, Clarissa C. Parker, Robert A. Philibert, Lara A. Ray, Richard R. Reich, Ronald L. Simons, Courtney J. Stevens, Rachel E. Thayer, Rachel F. Tyndale, Tamara L. Wall, Reinout W. Wiers, Michael Windle, Harriet de Wit

Product Details

ISBN-13: 9780262019699
Publisher: MIT Press
Publication date: 12/13/2013
Series: The MIT Press
Pages: 400
Product dimensions: 7.20(w) x 9.10(h) x 1.00(d)
Age Range: 18 Years

About the Author

James MacKillop is Associate Professor in the Department of Psychology at the University of Georgia, where he is also Associate Director of the William and Barbara Owens Institute for Behavioral Research, and Adjunct Associate Professor in the Department of Behavioral and Social Sciences at Brown University.

Marcus R. Munafò is Professor of Biological Psychology at the University of Bristol, UK.

James MacKillop is Associate Professor in the Department of Psychology at the University of Georgia, where he is also Associate Director of the William and Barbara Owens Institute for Behavioral Research, and Adjunct Associate Professor in the Department of Behavioral and Social Sciences at Brown University.

Marcus R. Munafò is Professor of Biological Psychology at the University of Bristol, UK.

Michael Windle is Professor of Public Health in the Department of Behavioral Sciences and Health Education at Emory University.

Table of Contents

Contributors ix

1 An Intermediate Phenotype Approach to Addiction Genetics James MacKillop Marcus R. Munafò 1

2 Electrophysiological Intermediate Phenotypes for the Detection of Genetic Influences on Alcoholism Mary-Anne Enoch 19

3 Differential Metabolism of Alcohol as an Intermediate Phenotype of Risk for Alcohol Use Disorders: Alcohol and Aldehyde Dehydrogenase Variants Tamara L. Wall Susan E. Luczak Daria Orlowska Danielle Pandika 41

4 Nicotine Metabolism as an Intermediate Phenotype Meghan J. Chenoweth Rachel F. Tyndale 65

5 Subjective Responses to Alcohol as an Endophenotype: Implications for Alcoholism Etiology and Treatment Development Lara A. Ray Markus Heilig 97

6 Subjective Drug Effects as Intermediate Phenotypes for Substance Abuse Leah M. Mayo Abraham A. Palmer Harriet de Wit 121

7 Developmental Considerations in Gene Identification Efforts Danielle M. Dick 141

8 Enhancing Addiction Genetics via Behavioral Economic Intermediate Phenotypes James MacKillop John Acker 157

9 Using Functional Magnetic Resonance Imaging to Develop Intermediate Phenotypes for Substance Use Disorders Rachel E. Thayer Kent E. Hutchison 189

10 Implicit Cognition: An Intermediate Phenotype for Addiction? Reinout W. Wiers Eske M. Derks Thomas E. Gladwin 207

11 The Role of Genetics in Addiction and the Expectancy Principle Mark S. Goldman Richard R. Reich 237

12 Intermediate Phenotypes for Alcohol Use and Alcohol Dependence: Empirical Findings and Conceptual Issues Michael Windle 257

13 Epigenetic Effects and Intermediate Phenotypes Steven R. H. Beach Meg Gerrard Gene H. Brody Ronald L. Simons Steven M. Kogan Frederick X. Gibbons Robert A. Philibert 275

14 Differential Sensitivity to Context: GABRG1 Enhances the Acquisition of Prototypes That Serve as Intermediate Phenotypes for Substance Use Ronald L. Simons Man Kit Lei Steven R. H. Beach Gene H. Brody Robert A. Philibert Frederick X. Gibbons Meg Gerrard 303

15 From Genes to Behavior Change: Treatment Response as an Intermediate Phenotype Courtney J. Stevens ollis C. Karoly Renee E. Magnan Angela D. Bryan 327

16 Using Intermediate Phenotypes to Bridge the Gap between Human and Mouse Genetics Clarissa C. Parker Abraham A. Palmer 345

Index 373

What People are Saying About This

From the Publisher

Genetic Influences on Addiction directly tackles the fundamental question of how genes scale-up to produce the patchwork of biological and psychological vulnerabilities that underpin addiction. The book's objective is crucial because stitching together this multiplicity of processes is essential for much needed advances in treatment efficacy.

Lee Hogarth , Associate Professor, School of Psychology, University of Exeter

Endorsement

Genetic Influences on Addiction directly tackles the fundamental question of how genes scale-up to produce the patchwork of biological and psychological vulnerabilities that underpin addiction. The book's objective is crucial because stitching together this multiplicity of processes is essential for much needed advances in treatment efficacy.

Lee Hogarth, Associate Professor, School of Psychology, University of Exeter

Lee Hogarth

Genetic Influences on Addiction directly tackles the fundamental question of how genes scale-up to produce the patchwork of biological and psychological vulnerabilities that underpin addiction. The book's objective is crucial because stitching together this multiplicity of processes is essential for much needed advances in treatment efficacy.

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