The 55th Nobel Symposium entitled "Genetics of the Immune Response" took place in Saltsjobaden, Sweden, June 15 - 17, 1982. The topic was selected for several reasons, such as the rapid progress in the genetic analysis of immunoglobulin and MHC genes and the elucidation of the mechanism of switch to different immunoglobulin classes and subclasses. The genetic advances formed a basis for discussions of problems relating to regulation of T cell subsets, mechanisms of activation and regulation of B cell differentiation and an analysis of the network hypothesis. The format of the symposium was arranged so as to include two sessions in the morning and two in the afternoon. Each session was introduced by one speaker, followed by free discussion. The intro ductory lectures are included in the proceedings. The participants summarized their contributions to the discussion in written form. In addi tion to the closed sessions, there was one open session at the Karolinska Institute with lectures by Drs. L. Hood, C. Milstein, D. Baltimore, J. Klein and B. Benacerraf, which are not included in these procee din gs. The symposium was sponsored by the Nobel Foundation and its Nobel Symposium Committee through grants from the Tercentenary Fund of the Bank of Sweden and the Knut & Alice Wallenberg Foundation. The Swedish Medical Research Council, the Swedish Cancer Society and the Swedish Ministry of Education and Cultural Affairs also made contri butions.
Table of ContentsSession I: Antibody V Genes.- The Formation of Antibody Variable Region Genes.- Discussion.- Session II: Antibody C Genes.- Organization and Reorganization of Constant Region Genes of Immunoglobulin Heavy Chains: Genetic Basis for Class Switching.- Discussion.- Session III: MHC Genes.- Molecular Analysis of MHC Antigens.- Discussion.- Session IV: MHC Antigens and T Cell Function.- Immunological Surveillance: T Cell Repertoire and the Biological Function of MHC Antigen.- Discussion.- Session V: Induction and Effector Functions of T Cells.- Induction and Effector Function of T Cells.- Discussion.- Session VI: T Cell Regulation.- T-Cell Growth Factor, A Lymphocytotropic Hormone.- Discussion.- Session VII: B Cell Differentiation.- Stimulation of a B Cell Subset by Anti-Immunoglobulin and T Cell-Derived Regulatory Molecules.- Discussion.- Session VIII: B Cell Regulation I.- The Degree of Clonal Elimination in Immunological Tolerance and Regulation of Heavy Chain Class.- Discussion.- Session IX: B Cell Regulation II.- Factors Determining Virgin and Postantigenic Repertoires of B Cell Population and Its Subsets.- Discussion.- Session X: Immune Networks.- Is the Network Theory Tautologic?.- Discussion.- List of Participants.