Pub. Date:
Elsevier Science & Technology Books
Genomic Regulatory Systems: In Development and Evolution / Edition 1

Genomic Regulatory Systems: In Development and Evolution / Edition 1

by Eric H. Davidson


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Genomic Regulatory Systems: In Development and Evolution / Edition 1

Genomic Regulatory Systems is about the gene regulatory programs built into the DNA of every animal. Such programs control the process of development, and changes in their organization are the underlying cause of animal evolution.
The book takes a "genome's eye" view of the mechanism of spatial gene regulation and of developmental processes ranging from simple forms of embryogenesis to elegant mechanisms of pattern formation. Throughout, discussions of development and evolution are intertwined. The text takes an in-depth look at how the hardwired control systems of the genome work and offers an explanation for evolutionary change in animal body plans.
Eric H. Davidson is a major contributor to the field of developmental biology and has long been interested in the relationship between development and evolution. Genomic Regulatory Systems is authoritative but easy-to-read and will appeal to professionals and readers from a wide variety of scientific backgrounds.
Contents Include
*Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution
* Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression
* Regulation of Direct Cell-Type Specification in Early Development
* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans

Product Details

ISBN-13: 9780122053511
Publisher: Elsevier Science & Technology Books
Publication date: 01/28/2001
Pages: 261
Product dimensions: 7.76(w) x 9.53(h) x 0.87(d)

About the Author

Eric H. Davidson is the Norman Chandler Professor of Cell Biology at the California Institute of Technology and a Member of the National Academy of Sciences.

Table of Contents

1.Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and its Causal Role in Development and Evolution
The Regulatory Apparatus Encoded in the DNA
The Genes and Gene Regulatory Components of Animal Genomes2
Overview of Regulatory Architecture7
Gene Regulatory Functions in Development11
The Regulatory Demands of Development11
Pattern Formation13
Terminal Differentiation16
Genomic Regulatory Sequence and the Evolution of Morphological Features18
Regulatory Evolution, and Evolution in General19
Bilaterian Phylogeny20
2.Inside the cis-Regulatory Module: Control Logic, and How Regulatory Environment is Transduced into Spatial Patterns of Gene Expression
Operating Principles for cis-Regulatory Systems that Mediate Developmental Specification Events26
Spatial Repression in cis-Regulatory specification28
Two Very Different Examples of Similar Import28
cis-Regulatory Design for Autonomous Modular Function35
The Generality of Repression41
Downstream of Specification44
Some Examples45
At the Beginning of Embryogenesis46
Polyfunctional Downstream Modules48
The "Power" of the cis-Regulatory Module49
Diverse cis-Regulatory Outputs from a Simple Input50
Direct Integration of Noncoincident Spatial Inputs52
A cis-Regulatory Logic Device54
3.Regulation of Direct Cell-Type Specification in Early Development
The Basic Package for Bilaterian Embryogenesis: Type 1 Specification Processes64
Regulatory Mechanism in Territorial Specification of the Sea Urchin Embryo66
The Definitive Territories of the Embryo66
Early Transcriptional Activation of Cell Type-specific Genes71
Initial Regulatory Processes74
Multiple Inputs for Endomesoderm Specification75
Regulatory Mechanisms Controlling Specification in Ascidian Embryos81
Territorial Specification81
Mechanisms and Pathways in Mesoderm Specification85
Caenorhabditis elegans: The Genomic Apparatus for Endoderm Specification92
Endoderm Specification93
The Network of Zygotic cis-Regulatory Interactions Required for Endoderm Specification96
Short Summary: Quality of Type 1 Regulatory Networks101
4.The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
The Evolutionary Significance of "Pattern Formation"103
The First Step: Transcriptional Definition of the Domain of the Body Part105
Morphological Pieces and Regulatory Subpatterns110
Heart Parts110
Forelimb and Hindlimb Buds111
Transcriptional Domains in the Gut Endoderm115
Patterns in the Developing Hindbrain117
Appendage Parts and Transcriptional Patterns in Drosophila Imaginal Discs121
Glimpses of How It Works122
Transcriptional Domains and the Pattern Program for the Drosophila Wing Disc: Modularity and cis-Regulatory Inputs123
Patterning the Heart Progenitor Field in Drosophila129
Encoding Hindbrain Regulatory Patterns131
The Role of Signaling140
The Last Routines: Calling in Differentiation Programs146
Specification of Peripheral Nervous System Elements in the Drosophila Wing147
Installation of Cell Type-specific Differentiation Programs in the Pituitary152
Concluding Remark153
5.Changes that Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Some Examples: Evolutionary Cooption of Genes to New Pattern Formation Functions158
hox Gene Functions and Cooptions of the hox Cluster Patterning System164
A Specific Case of A/P Patterning: How a hox Gene Does Its Job166
Evolutionary Changes in hox Gene Expression in the Arthropods167
Off the A/P Axis174
Colinear Expression of hox Genes in the Somatocoels of Sea Urchin Larvae178
Small Changes183
Evolutionary Origins of Body Parts188
Polarity in Body Part Evolution188
The Case of pax6 and Some Other Amazing Examples191
Concluding Comment: Conceiving Evolution as a Process of Change in Regulatory Gene Networks201

What People are Saying About This

Leroy Hood

Davidson's book is a fascinating exposition of the role regulatory networks play in both development and evolution. He writes with a clarity and insight that propels us into some of the most fascinating issues in contemporary biology. A must-read for all true students of biology.
—(Dr. Leroy Hood, Institute for Systems Biology)

M. Levine

M. Levine, UC Berkeley
Davidson provides a vivid account of how cis-regulatory DNA integrates complex signals to control the on/off activities of gene batteries during metazoan development. The often neglected "non-coding" genomic DNA is finally brought to life through the use of illuminat-ing examples that span a broad spectrum of experimental systems. The book should appeal to students and researchers in the areas of development and evolution, as well as to com-putational biologists who are interested in modeling gene networks.

D. Erwin

D. Erwin, Smithsonian Institute
Probably the highest praise I can give a book after finishing it is to want to start reading it all over again. This is that sort of book...a great job in synthesizing enormous quantity of information into a digestible perspective on regulatory patterns and their importance for evolution. I learned an incredible amount from the book...

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