Geriatric Bioscience: The Link between Aging and Disease

Geriatric Bioscience: The Link between Aging and Disease

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Johns Hopkins University Press
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Geriatric Bioscience: The Link between Aging and Disease

It is increasingly important for physicians who treat older persons, and for researchers on aging, to understand how molecular biology informs clinical expressions of aging and age-related conditions such as osteoporosis, diabetes, osteoarthritis, frailty, cancer, and dementia. Dr. David Hamerman translates basic scientific concepts into precepts of clinical practice and sheds light on the links among biology, natural aging, longevity, and disease.

Exploring the connections between disease and the science behind it, Geriatric Bioscience addresses how mechanisms of inflammation, cytokine expression, and stress responses influence disease and how preventive gerontology in the practice of medicine could compress morbidity. Hamerman also discusses cutting-edge therapies such as cyclo-oxygenases, bisphosphonates, statins, cytokine inhibitors, and hormone therapies.

Examining the science of geriatrics and converting its concepts into clinical applications, this groundbreaking work provides clinicians and researchers with a solid foundation for a greater understanding of the diagnosis, treatment, and prevention of age-related diseases as well as recommendations for promoting healthy aging.

Product Details

ISBN-13: 9780801886928
Publisher: Johns Hopkins University Press
Publication date: 10/31/2007
Edition description: New Edition
Pages: 316
Product dimensions: 6.00(w) x 9.00(h) x 1.00(d)

Table of Contents

Foreword   Robert N. Butler     vii
Preface     ix
The Emergence and Future of Geriatrics     1
An Introduction to Concepts of Molecular Biology   E. Richard Stanley     13
Aging     25
Trends in the Aging of the Population     25
What Is Aging? Can We Distinguish between Aging and Disease?     28
Mechanisms of Aging     31
Longevity: Genetics of Extended Life Span or Risk for Adverse Events     41
Interrelations of Certain Aging-related Conditions     50
Cytokines, Inflammation, and Responses to Stress     50
Atherosclerosis: Risk Factors for Cardiovascular Disease     58
The Metabolic Syndrome and Type 2 Diabetes     64
Osteoporosis     97
Osteoarthritis     121
Frailty and Related Conditions: Anorexia, Sarcopenia, Exercise     132
Cancer     145
Alzheimer Disease   Peter Davies     155
Interactive Therapies Significant for an Aging Population     169
Cyclooxygenases     169
Statins     173
Bisphosphonates     180
Thiazolidinediones and Peroxisome Proliferator-activated Receptory [gamma]     183
CytokineInhibitors as a Landmark for Newer Anti-inflammatory Therapies     192
Hormonal Therapies     199
Preventive Gerontology     209
The Compression or Expansion of Morbidity?     209
Healthy Lifestyle Practices     211
"Successful Aging"     214
Epilogue     216
Glossary     223
References     227
Index     281

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