Gestational Trophoblastic Disease: Diagnostic and Molecular Genetic Pathology

Gestational Trophoblastic Disease: Diagnostic and Molecular Genetic Pathology

by Pei Hui (Editor)

Hardcover(2012)

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Product Details

ISBN-13: 9781617793936
Publisher: Springer-Verlag New York, LLC
Publication date: 12/14/2011
Series: Current Clinical Pathology
Edition description: 2012
Pages: 205
Product dimensions: 7.01(w) x 10.00(h) x 0.03(d)

Table of Contents

Forward

Preface and Dedication

Chapter 1: Gestational Trophoblastic Disease: General Aspects (Pei Hui)

- Historical remarks

- Definition and classification of gestational trophoblastic disease

- Epidemiology and risk factors

- Overview of diagnosis

- Overview of clinical management

- Perspectives

- References

Chapter 2: Developmental Biology of the Placenta (Pei Hui)

- Introduction

- Placenta formation

- Stages of implantation

- Placental trophoblastic cells

- Genomic imprinting and placental development

- Imprinted X chromosomal inactivation and placental development

- Co-evolution of genomic imprinting and imprinted X-chromosome inactivation

- “Parental conflict of interest” theory of genomic imprinting

- References

Chapter 3: Genetic Basis of Gestational Trophoblastic Disease (Pei Hui)

- Introduction

- Androgenetic nature of hydatidiform moles

- Genomic imprinting and hydatidiform moles

- Genetic basis of gestational trophoblastic tumors

- Perspectives

- References

Chapter 4: Complete hydatidiform mole (Pei Hui)

- Introduction

- Pathogenesis

- Clinical presentation

- Pathology

- Ancillary studies

- Differential diagnosis

- Clinicopathological correlations

- References

Chapter 5: Partial hydatidiform mole (Natalia Buza)

- Introduction

- Genetic background

- Clinical presentation

- Pathology gross and microscopic features

- Ancillary studies

- Differential diagnosis

- Clinicopathological correlations

- References

Chapter 6: Placental site trophoblastic tumor (PSTT) (Pei Hui)

- Introduction

- Clinical presentation

- Pathogenesis

- Gross and histological pathology

- Ancillary studies

- Differential diagnosis

- Clinicopathological correlations

- References

Chapter 7: Epithelioid trophoblastic tumor (Katja Gwinn)

- Introduction

- Pathogenesis and molecular genetic aspect

- Clinical presentation

- Pathology

- Ancillary studies

- Differential diagnosis

- Clinicopathological correlations

- References

Chapter 8: Gestational choriocarcinoma (Pei Hui)

- Introduction

- Clinical presentation

- Pathogenesis

- Pathology

- Ancillary studies

- Differential diagnosis

- Clinicopathological correlations

- References

Chapter 9:Persistent gestational trophoblastic neoplasia (Pei Hui)

- Introduction

- Pathology

• Persistent mole

• Invasive mole and metastatic mole

• Gestational trophoblastic tumors

- Prognosis

- References

Chapter 10:Tumor-like trophoblastic conditions (Pei Hui)

- Introduction

- Placental site nodule/plaque (PSN)

• Clinical features

• Pathogenesis

• Pathology

• Ancillary studies

• Differential diagnosis

• Clinicopathological correlations

- Exaggerated placental site reaction (EPS)

• Clinical features

• Pathogenesis

• Pathology

• Ancillary studies

• Differential diagnosis

• Clinicopathological correlations

- References

Chapter 11:Molecular Diagnosis of Gestational Trophoblastic Disease (Pei Hui)

- Introduction

- Genetic basis of molecular testing

- Methods of molecular diagnosis

- STR genotyping diagnosis of hydatidiform moles

- Interpretation of STR PCR data

- Target tissue selection and processing

- Diagnostic pitfalls of STR genotyping

- STR genotyping diagnosis of trophoblastic tumors

- Prospective

- Conclusions

- References

Chapter 12: Clinical aspects of gestational trophoblastic disease (Christine E. Richter and Peter E. Schwartz)

- Introduction

- Diagnosis

- Hydatidiform moles

- Gestational trophoblastic neoplasia

- Treatment of gestational trophoblastic neoplasia

- Treatment of PSTT and ETT

- Treatment failure GTN

- Follow-up GTN

- References

Appendix:

GTD clinicopathological staging forms (AJCC 2010, Seventh Edition, Springer)

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