Wild-child Drake and goody-goody Josh are as different as two kids can be-- the only things they share are their families and their room!
Drake and Josh are left "home alone" for 10 days, and chaos ensues. First they put Megan, their kid sister, on a plane bound for Los Angeles instead of Denver. Then, when they go looking for her, they end up mixed-up in a counterfeiting scheme, stealing Tony Hawk's car, guesting on MTV's TRL, and, of course, flirting with cute girls. The only question is: how to get it all straightened out and still get home before their parents!