Growth Factors and Signal Transduction in Development Edited by Marit Nilsen-Hamilton, Professor of Biochemistry, Department of Biochemistry and Biophysics, Iowa State University Animal development relies on the interaction of complex combinations of growth factors and their receptors. It has been discovered that many growth factors have the option of more than one receptor for signal transduction. Furthermore, these receptors can be expressed differently in different cell types and in the developing organism. This discovery points to the potential for fine regulation of the individual cellular response to growth factors. Growth Factors and Signal Transduction in Development thoroughly describes the interactions of several key growth factors, their receptors, and the subsequent signal transduction pathways they activate. This volume emphasizes the role of these signal pathways in directing developmental events. The editor has organized this book to contrast different signaling pathways using specific growth factors as paradigms: FGF IGF-1 PDGF IL-2 EGF TGFß Leading experts in the field have contributed to the unique mix of both molecular and biochemical perspectives as well as more integrative and organismal treatments of the well-studied amphibian, nematode, and insect developing systems. Significant aspects of mouse development are included in chapters that focus on particular growth factors. Most chapters contain comparative analyses of the role of growth factors, as well as their signal transduction mechanisms in these different developing systems. A notable feature of Growth Factors and Signal Transduction in Development is its glossary of genes and proteins referred to in this volume. It is designed to enhance an understanding of the relationship between genes and their protein products and enzymatic activities. The book’s integrative approach to the subject will prove especially useful to graduate students and researchers as well as research specialists in the areas of biochemistry, and molecular, cellular, and developmental biology.
Table of Contents
The Insulin Family of Growth Factors and Signal Transduction During Development (C. Ward, et al.).
Developmental Regulation and Signal Transduction Pathways of Fibroblast Growth Factors and Their Receptors (K. Miller & A. Rizzino).
Platelet-Derived Growth Factor in Development (D. Bowen-Pope & R. Seifert).
T-Cell Signalling and Activation Through the Interleukin-2 Receptor Complex (N. Terada, et al.).
The Transforming Growth Factor β Family in Vertebrate Embryogenesis (R. Akhurst).
The Ras Signal Transduction Pathway in Development (R. Hamilton).
Protein Phosphatases in Cell Proliferation, Differentiation, and Development (T. Ingebritsen, et al.).
Growth Factors and Signal Transduction in Drosophila (E. Liebl & F. Hoffman).
Cell Interactions and Signal Transduction in C.
elegans Development (S. Tuck & I. Greenwald).
Embryonic Induction and Axis Formation in Xenopus laevis: Growth Factor Action and Early Response Genes (I. Dawid).
Acronyms Used in This Volume.
Glossary of Proteins and Their Genes and Gene Families.