This volume comprises the written contributions of participants in a symposium held in Dallas, Texas, June 3-5, 1980, entitled "HAMSTER IMMUNE RESPONSIVENESS AND EXPERIMENTAL MODELS OF INFECTIOUS AND ONCO LOGIC DISEASES". This meeting followed its predecessor, "Hamster Immune Responses: Experimental Models Linking Immunogenetics, Oncogene sis and Viral Immunity" by three years. This more recent meeting was more pointed in its focus and the contributions appeared to be more tightly associated. These meetings are part of an extend~d effort by experimentalists using the Syrian hamster as an animal model system to bring together workers in potentially related areas for the exchange of ideas and information. The success of the symposia derives partly from the scientific excellence of the contributing scientists, and partly from the financial support of the National Institutes of Health through the Fogarty International Center. The administration of the University of Texas Health Science Center at Dallas, under President Charles C. Sprague, also donated time, facilities, and financial sup port. Preparation of the manuscripts in this volume, as camera-ready copy for the publisher, was the diligent and dedicated effort of Ms. Sara Howard. Copy editing was expertly performed by Ms. Sandra Schulte and proof-reading was the responsibility of Dr. Patricia Fultz and Ms. Alix Gerboth. However, final responsibility for any errors and omis sions in the published volume is taken by the five local editors: J. Wayne Streilein David A. Hart Joan Stein-Streilein William R. Duncan R. E.
Table of ContentsSection I Immune Responses in Vitro and in Vivo.- Hamster Lymphoid Cell Responses in Vitro.- Syrian Hamsters Express Polymorphism at an MHC Equivalent.- IgE-Dependent Release of Inflammatory Mediators from Hamster Mast Cells in Vitro.- Induction and Regulation of Contact Hypersensitivity in Syrian Hamsters.- Allergic Contact Dermatitis in the Hamster and Other Rodents.- Section II Molecular Immunology.- Immunochemical Characterization of Syrian Hamster Major Histocompatiblity Complex Homologues.- Immunoglobulins on the Surfaces of Hamster Lymphocytes.- Comparative Immunology of Old World Hamsters Cricetinae.- Hemolytic Complement and Its Components in Syrian Hamsters: A Study of Five Strains Uninfected and Infected with Brugia Pahangi.- Isolation and Characterization of Hamster Alpha2 Macroglobulin.- Section III Effector Cells in Viral and Tumor Immunity.- Functional Analysis of Lymphoid Cell Subpopulations Involved in Rejection of Tumors Induced by Simian Virus 40.- Natural Cytotoxicity by Hamster Lymphoid Cells for Virus-Infected and Transformed Cells.- The Hamster Major Histocompatibility Complex and Alternate Mechanisms of Cell-Mediated Anti-Viral Cytotoxic Activity in the Syrian Hamster.- Natural Killer (NK) Cells in Hamsters and Their Modulation in Tumorigenesis.- Prevention of Primary Simian Adenovirus Type 7 (SA7) Tumors in Hamsters by Adoptive Transfer of Lymphoid Cells: Role of Different Cell Types.- Relationship between SV40-transformed Cell Susceptibility to Macrophage Killing and Tumor Induction in Rodents.- Section IV Pulmonary Immunology.- Immune Responses Related to the Hamster Lung.- Functional Heterogeneity of Alveolar Macrophages.- Anti-Viral Cytotoxic Lymphocyte Response in Hamsters with Parainfluenza Virus Type 3 Infection.- Mechanisms of Inflammation in Lung Tissue.- Section V Responses to Non-Viral Pathogens.- Immune Response of the Hamster to Experimental Mycoplasma Pneumoniae Disease.- Hemadsorption and Virulence of Mycoplasma Pneumoniae.- Experimental Filariasis in Hamsters; Immunological Aspects of Complex Host-Parasite Interactions.- Transmissible Ileal Hyperplasia.- LSH Hamster Model of Syphilitic Infection and Transfer of Resistance with Immune T Cells.- Section VI Responses to Viral Infections.- Experimental Subacute Sclerosing Panencephalitis (SSPE) in the Hamster.- Enhanced Intrauterine Transmission of Herpes Simplex Virus Infection in Immunosuppressed Hamsters.- Susceptiblity to Fatal Pichinde Virus Infection in the Syrian Hamster.- Genetically Determined Resistance to Lethal Vesicular Stomatitis Virus in Syrian Hamsters.- Defective Interfering Virus Particles and Their Biological Functions.- Section VII Infections with Unconventional Agents.- Effect of Vaccinia-Activated Macrophages on Scrapie Infection in Hamsters.- Use of the Golden Syrian Hamster in Study of Scrapie Virus.- Hamster Scrapie: Evidence for Alterations in Serotonin Metabolism.- Determination of Scrapie Agent Titer from Incubation Period Measurements in Hamsters.- Toward Development of Assays for Scrapie-Specific Antibodies.- Section VIII Viral Oncogenesis and Immune Responses.- An Immune- and Hormone-dependent Phase During the Latency Period of SV40 Oncogenesis in Syrian Hamsters.- The Implications of the Different Tumor-Inducing Capacities of Adenovirus-2 and SV40-Transformed Hamster Cells.- Modifications of the Lymphoid B and T Cell Populations in Spleen and Thymus of Tumor-Bearing Hamsters.- C-Type Particles in Thymic Development: A Correlation with Thymus Function.- Summation.