Handbook of Basic Pharmacokinetics...including Clinical Applications

Handbook of Basic Pharmacokinetics...including Clinical Applications


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Product Details

ISBN-13: 9780917330735
Publisher: APhA Publications
Publication date: 01/28/1999
Edition description: REV
Pages: 563
Product dimensions: 4.20(w) x 8.52(h) x 1.00(d)

Table of Contents

Preface1. Definitions and Glossary 2. The LADMER System¿Liberation, Absorption, Distribution, Metabolism, Elimination, and Response 3. Organs, Tissues, Cells, and Organelles 4. Cell Membranes 5. Drug–Receptor Interactions 6. Absorption/Transport Mechanisms 7. pKa and Degree of Ionization 8. Lipid/Water Partition Coefficient 9. Physicochemical Factors Altering Biological Performance of Drugs 10. Biopharmaceutical Data of the Gastrointestinal Tract 11. Fluid Compartments and Circulatory System 12. Binding of Drugs to Biological Material 13. Drug Biotransformation 14. Compartment Models 15. Determination of Rate Constants 16. Volume of Distribution and Distribution Coefficient 17. Excretion and Clearance of Drugs 18. Urinary and Biliary Recycling 19. Cumulative Urinary Excretion 20. Area Under the Blood Level–Time Curve 21. Pharmacokinetics of Single Dose Administration 22. Pharmacokinetics of Multiple Dosing 23. Compartment Model Independent Analysis (and more...)

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