Handbook of Chiral Chemicals

Handbook of Chiral Chemicals

by David John Ager (Editor)


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In the context of the move by pharmaceutical companies to develop single enantiomers as drug candidates, researchers from companies and a few universities in Europe, North America, and Australia highlight the problems associated with producing chiral compounds at a commercial scale. They survey the major classes of natural products and describe an array of techniques. No date is noted for the first volume; all the chapters have been updated, and new chapters added for the second. Annotation © 2006 Book News, Inc., Portland, OR

Product Details

ISBN-13: 9780824710583
Publisher: Taylor & Francis
Publication date: 01/01/1999
Pages: 384
Product dimensions: 6.24(w) x 9.18(h) x 1.08(d)

Table of Contents

1. Introduction 2. Amino Acids 3. Microbial Pathway Engineering for Amino Acid Manufacture 4. Carbohydrates in Synthesis 5. Terpenes: The Expansion of the Chiral Pool 6. Resolutions at Large Scale: Case Studies 7. New Developments in Crystallization-Induced Resolution 8. The Role of cis-1-Amino-2-Indanol in Resolution Processes 9. Asymmetric Oxidations 10. Asymmetric Epoxidation of Olefins by Chiral Ketones 11. Ozonolysis in the Production of Chiral Fine Chemicals 12. Transition Metal Catalyzed Hydrogenations, Isomerizations, and Other Reactions 13. Modular, Chiral P-Heterocycles in Asymmetric Catalysis 14. Asymmetric Olefin Hydrogenation Using Monodentate BINOL- and Bisphenol-Based Ligands: Phosphonites, Phosphites, and Phosphoramidites 15. Asymmetric Catalytic Hydrogenation Reactions with Ferrocene-Based Diphosphine Ligands 16. Asymmetric Reduction of Prochiral Ketones Catalyzed by Oxazaborolidines 17. cis-1-Amino-2-Indanol-Derived Ligands in Asymmetric Catalysis 18. Enantioselective Hydrogenation of Activated Ketones Using Heterogeneous Pt Catalysts Modified with Cinchona Alkaloids 19. Biotransformations: “Green” Processes for the Synthesis of Chiral Fine Chemicals 20. Combining Enzyme Discovery and Evolution to Develop Biocatalysts 21. One-Pot Synthesis and the Integration of Chemical and Biocatalytic Conversions 22. Substitution Reactions 23. Industrial Applications of Chiral Auxiliaries 24. The Role and Importance of cis-1-Amino-2-Indanol in Biological Systems and Asymmetric Processes 25. Enantiopure Amines by Chirality Transfer Using (R)-Phenylglycine Amide 26. Pericyclic Reactions 27. Asymmetric Free-Radical Reductions Mediated by Chiral Stannanes, Germanes, and Silanes 28. Metathesis Reactions 29. Synthesis of Homochiral Compounds: A Small Company’s Role 30. Commercial Synthesis of the Antiglaucoma Prostanoid Travoprost 31. Synthesis of Large Volume Products

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