ISBN-10:
1420076477
ISBN-13:
9781420076479
Pub. Date:
11/03/2008
Publisher:
Taylor & Francis
Handbook of Drug Metabolism, Second Edition / Edition 2

Handbook of Drug Metabolism, Second Edition / Edition 2

by Paul G. Pearson, Larry C. Wienkers

Hardcover

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Product Details

ISBN-13: 9781420076479
Publisher: Taylor & Francis
Publication date: 11/03/2008
Series: Drugs and the Pharmaceutical Sciences Series , #186
Pages: 616
Product dimensions: 7.30(w) x 10.00(h) x 1.50(d)

Table of Contents

1. Introduction to History of Drug Metabolism. 2. Morphofunctional Aspects of the Hepatic Architecture: Functional and Subcellular Correlates. 3. The Cytochrome P450 Oxidative System. 4. Transformation Enzymes: Oxidative; Non-P450. 5. Transformation Reactions: Glucuronidation. 6. Pharmacokinetics of Drug Metabolites. 7. Oxidative Metabolic Bioactivation of Xenobiotics. 8. Pharmacogenetics. 9. Inhibition of Drug Metabolizing Enzymes: Molecular and Biochemical Aspects. 10. Sites of Extra Hepatic Metabolism part I: Lung. 11. Sites of Extra Hepatic Metabolism part II: Gut. 12. Sites of Extra Hepatic Metabolism part III: Kidney. 13. Sites of Extra Hepatic metabolism part IV: Brain. 14. Drug Metabolizing Enzymes / Transporters Interplay. 15. Applications of Heterologous Expressed and Purified Human Drug-Metabolizing Enzymes: An Industrial Perspective. 16. In Vitro Metabolism: Subcellular Fractions. 17. In Vitro Metabolism: Hepatocytes. 18. The Isolated Perfused Liver as a Tool in Drug Metabolism Studies. 19. The Role of Nuclear Magnetic Resonance Spectroscopy in Drug Metabolism. 20. Induction Studies Drug Metabolizing Enzymes. 21. Experimental Characterization of Mechanism Based Inhibition. 22. Computational Metabolism Studies in Drug Discovery
LC/MS analysis in Drug Metabolism Studies. 23. Drug Metabolism/Drug Interaction. 24. Studies in the Drug Development Process: Studies In Vitro. 25. Clinical Drug Metabolism Studies. 26. Covalent Protein Binding in Drug Discovery. 27. Metabolites in Safety Testing Special Considerations. 28. LM Disposition and PK. 29. Transgenic Animals to Study Drug Metabolism. 30. Ontogeny of Drug Metabolizing Enzymes / Pediatric Exclusivity. 31. Animal Models to Understand Metabolism and Disposition Issues.

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