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Handbook of Hypertension / Edition 1

Handbook of Hypertension / Edition 1

by Mark Houston


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Product Details

ISBN-13: 9781405182508
Publisher: Wiley
Publication date: 05/05/2009
Pages: 412
Product dimensions: 5.50(w) x 8.40(h) x 1.00(d)

About the Author

Mark C. Houston, MD, MSc, FACP, FAHA
Associate Clinical Professor of Medicine
Vanderbilt University School of Medicine
ASH Specialist in Clinical Hypertension
Director, Hypertension Institute and Vascular Biology, Nashville,Tennessee
Section Chief, Division of Nutrition and Clinical Research
Staff Physician, Vascular Institute
Saint Thomas Hospital
Nashville, Tennessee

Table of Contents

Provisional Table of Contents.


General Introduction .


Hypertension Syndrome.

Vascular Biology.

Functional Endothelium.

Endothelial Dysfunction.

New Treatment Approach.

Hypothesis: Essential Hypertension and End-OrganDamage.

Hypertension Classification and Guidelines Wordwide.

Hypertension in the US.








JBS 2.

Global Cardiovascular Risk Calculation.

Secondary Hypertension.

Measurement of Blood Pressure.

Indirect measurement of blood pressure.

Korotkoff Sounds.

Common Mistakes in Blood Pressure Measurement.

Hypertension-Atherosclerotic Syndrome.

Normotensive Hypertension.


Nonpharmacologic Treatment of Hypertension.


Nutraceuticals, Vitamins, Minerals and Antioxidants.

DASH I and II Trials.

Specific Recommendations.



Approaches to Selection of Antihypertensive Therapy.

Stepped Care.


Subsets of Hypertension.

Renin Profiling: The Laragh Method.

Hemodynamics in Hypertension.

Hemodynamics: Logical and Preferred Method to Reduce BloodPressure.

Hemodynamic Effects of Antihypertensive Drugs.

Hypertension-Related End-Organ Damage.

Life Expectancy and Blood Pressure.

Systolic, Diastolic and Pulse Pressure Concepts.

Isolated Systolic Hypertension.

Clinical Hypertension Trials and Antihypertensive .

Drug Therapy .

Completed Trials and Trials in Progress.

Diuretic and Beta-Blocker Trials.

Summary of Clinical Trials with Diuretics.

Summary of Clinical Trials with Beta-Blockers.

Meta-Analysis of Various Clinical Trials.

Comparisons of ACE-Inhibitor therapy with Placebo.

Comparisons of Calcium-antagonist therapy with Placebo.

Comparisons of More Intensive Blood Pressure Lowering Strategieswith Less.

Intensive Strategies.

Comparisons of Ace-Inhibitor based Therapy with Diuretic-basedor Beta-Blocker Therapy.

Comparisons of Calcium-antagonist-based Therapy with Diuretic orBeta-BlockerTherapy.

Comparisons of Ace-Inhibitor Therapy with Calcium-antagonistTherapy.

Summary of Clinical Trials in Hypertension and ClinicalOutcomes.

Health Outcomes Meta-Analysis.

Comparing the CCBs to other Antihypertensive Therapy.


ALLHAT: Conclusions.

ASCOT Trial.

Summary of Published Trials Involving CCBs.

Angiotensin Converting Enzyme Inhibitors (ACEI) Trials.

Summary of ACEI Trials.

Angiotensin Receptor Blockers (ARBs) Trials.

ARBs Trials Summary.

Coronary Heart Disease Risk Factor and Effects ofAnti-hypertensive Drug Therapy.

Coronary Heart Disease: Risk Factors.

Coronary Heart Disease Risk Factors: More potential riskfactors.

Influence of Diuretic and Beta-Blocker Therapy on CHD RiskFactors.

Antihypertensive Drugs and Serum Lipids.

Summary of Serum Lipids and Antihypertensive Therapy withDiuretics and.

Beta Blockers.

Effects of Antihypertensive Drugs on Coronary Heart Disease RiskFactors.

Antihypertensive Drugs and Coronary Heart Disease Risk Factors:Summary.

Calcium Channel Blockers and Atherosclerosis (CHD ReductionTrials).

Hypertension and Renal Disease.

Classification of Chronic Kidney Disease.

Hypertension and Renal Damage.

Hypertension-Related Renal Damage:.

Postulated Mechanisms.

Is Thiazide Diuretic-Based Antihypertensive Therapy Associatedwith Increased.

Risk of Renal Injury.

Major Clinical Trials Showing Renoprotection.

Effects of Antihypertensive Drugs on Renal Function.

Hypertension and Diabetes Mellitus.

Hypertensive Diabetics: Mortality, Coronary Heart Disease andAntihypertensive.


BP Level Effects on Type II-DM Nephropathy.


Diabetes Mellitus and Hypertension Summary.

Selection of Therapy Based on Subsets ofHypertension.

Demographics and Antihypertensive Drugs.

Resistant Hypertension.

Isolated Systolic Hypertension in the Elderly.

Hypertensive Urgencies and Emergencies.

Treatment; General Principles.

Treatment; Choice of Drug.

Treatment of Specific Hypertensive Disorders.

Hypertension in Pregnancy.

General Review of Antihypertensive Drug Therapy.

Quality of Life and Antihypertensive Therapy (SelectedTrials).

Antihypertensive Drug Compliance.

Total Cost of Antihypertensive Therapy.

Characteristics of the Ideal Antihypertensive Drug.

Combination Antihypertensive Therapy: Selected Drugs.

Combination Antihypertensive Therapy: Selected Drugs:Summary.

Antihypertensive Therapy: Efficacy of Monotherapy.

Selected Drug Interactions with Antihypertensive Therapy.

Maximum Recommended Doses of Antihypertensive Drugs with BestTreatment Characteristics.

Specific Review of all Antihypertensive Drug Classes.


Diuretics Highlights.

Central Alpha-Agonists.

Central Alpha-Agonists: Similarities.

Central Alpha-Agonists: Highlights.

Comparison of Commonly Used Oral Central Alpha-Agonists.

Postganglionic Neuron Inhibitors.

Postganglionic Neuron Inhibitors Highlights.


Side Effects and Contraindications of Beta-Blockers.

Drug Interactions with Beta-Blockers.

Beta-Blockers Highlights.

Direct Vasodilators.

Direct Vasodilators Highlights.


Alpha1-Blockers: Highlights.

Angiotensin-Converting Enzyme (ACE) Inhibitors.

Renin-Angiotensin System (RAAS).

ACE Inhibitors: Highlights.

Non Hypertensive Treatment Effects of ACEIs.

Calcium Channel Blockers.

Calcium Channel Blockers: Highlights.

Treatment: Non Hypertensive Effects of CCBs.

Angiotensin II Receptor Blockers (ARBs).

Ang-II Receptor Blockers (ARBs): Highlights.

Non Hypertensive Treatment effects of ARB’s.

Renin Inhibitors.

Serum Aldosterone Receptor Antagonists (SARA’s).

Combination of Anti-hypertensive Drug with Statin ( Amlodipinewith Atorvastatin).

Arterial Compliance: Structure/Function: Treatment.

Selected Combination Antihypertensive Drugs.

Hypertension Drug Selection: Summary.

New Antihypertensive Drug Classes.

Subset Selection of Antihypertensive Therapy.

Conclusions 383.

References 385.

Index 400.

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