The link between Helicobacter pylori infection and ulcer disease has been one of the most significant discoveries in the past decade. The role of this organism in the development of non-ulcer dyspepsia, gastric cancer, lymphoma and even heart disease is also attracting much interest.
For those whose speciality lies outside of gastroenterology it is extremely difficult to keep abreast of this rapidly moving area. In the last year alone (1998), 1,300 works on Helicobacter pylori have been published. With this in mind, The Helicobacter pylori Handbook provides a concise and up-to-date review of H.pylori infection, with updated sections on its diagnosis and treatment, and the position of H.pylori eradication in the management of gastrointestinal disorders.
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Table of Contents
1. H. pylori: the micro-organism:.
1.1 History links micro-organism and ulcers;.
1.2 The discovery of H. pylori;.
1.3 The scale of the problem;.
1.5 Transmission of H. pylori;.
1.6 The host response to infection;.
2. H. pylori: the clinical problem:.
2.1 Classification of gastritis:.
2.2 H. pylori, gastritis and non-ulcer dyspepsia;.
2.3 H. pylori and peptic ulcer disease:.
2.3.1 Duodenal ulceration;.
2.3.2 Gastric ulceration;.
2.3.3 Evidence linking H. pylori with peptic ulceration;.
2.4 H. pylori and gastric cancer;.
2.5 H. pylori in children;.
3. Management of H. pylori infection:.
3.1 Detection of H. pylori:.
3.1.1 Direct tests;.
3.1.2 Indirect tests;.
Biopsy urease test;.
Urea breath tests;.
3.2 Treating H. pylori infection:.
In vitro effects;.
3.2.2 Dual therapy;.
Bismuth and metronidazole;.
Omeprazole and amoxycillin;.
Omeprazole and clarithromycin;.
3.2.3 Triple therapy;.
Bismuth triple therapy;.
Acid-suppressant triple therapy;.
3.2.4 Quadruple therapy;.
3.2.5 Ranitidine bismuth citrate;.
3.2.6 Eradication or suppression?.
3.3 Who should receive H. pylori treatment?.
4. Managing dyspeptic conditions in the H. pylori era:.
4.1 Patients with peptic ulceration:.
4.1.1 H. pylori eradication;.
4.1.2 Suggested H. pylori eradication treatment for patients with duodenal ulcer disease;.
4.2 Patients with dyspepsia;.
4.3 Where are we going in the future?.