High Throughput Screening: Methods of Protocols

High Throughput Screening: Methods of Protocols

by William P. Janzen (Editor)

Hardcover

$125.00

Product Details

ISBN-13: 9780896038899
Publisher: Springer-Verlag New York, LLC
Publication date: 01/28/2002
Series: Methods in Molecular Biology Series
Pages: 265
Product dimensions: 6.10(w) x 9.20(h) x 0.80(d)

Table of Contents

Prefacev
Contributorsix
1Design and Implementation of High Throughput Screening Assays1
2Configuring Radioligand Receptor Binding Assays for HTS Using Scintillation Proximity Assay Technology31
3Homogeneous Techniques for Monitoring Receptor--Ligand Interactions51
4Comparison of SPA, FRET, and FP for Kinase Assays65
5Electrochemiluminescence: A Technology Evaluation and Assay Reformatting of the Stat6/P578 Protein--Peptide Interaction87
6Cellular Assays in HTS107
7Compound Library Management117
8Compound Library Management: An Overview of an Automated System129
9Natural Products or Not? How to Screen for Natural Products in the Emerging HTS Paradigm153
10Introduction to Screening Automation169
11Unit Automation in High Throughput Screening195
12Fully Automated Screening Systems213
13Management and Maintenance of High Throughput Screening Systems229
Index247

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