Homocysteine in Health and Disease

Homocysteine in Health and Disease


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High levels of homocysteine, a sulfur-containing amino acid derived from methionine, have recently been identified as a very important risk factor in cardiovascular disease. Homocysteine abnormalities are also thought to contribute to birth defects and dementia. There are many common genetic disorders and problems (such as vitamin deficiency) that adversely affect the metabolism of homocysteine. In this book a team of the world's experts in the field provide a clear, current, clinical analysis of the biochemistry, genetics, and epidemiology of homocysteine disorders, providing a uniquely comprehensive account of the broad range of medical, nutritional and methodological implications of homocysteine for health and disease.

Product Details

ISBN-13: 9781107402423
Publisher: Cambridge University Press
Publication date: 07/21/2011
Pages: 536
Product dimensions: 8.27(w) x 11.02(h) x 1.06(d)

Table of Contents

1. Introduction: historical overview and recent perspectives David Wilken and Bridget Wilken; Part I. Biochemistry and Physiology; Section I. Chemistry: 2. Practical chemistry of homocysteine and other thiols Donald W. Jacobsen; 3. Biosynthesis and reactions of homocysteine thiolactone Hieronim Jakubowski; 4. Homocysteine and lipid oxidation Jay W. Heinecke; 5. Homocysteine, nitric oxide and nitrosothiols Andrew J. Gow, Fred Cobb and Jonathan S. Stamler; Section II. Biochemistry and metabolism: 6. Biosynthesis of S-adenosylmethionine Jose M. Mato, Matias A. Avila and Fernado J. Corrales; 7. S-adenosylmethionine-dependent methyltransferase Steven G. Clarke and Kelly Banfield; 8. S-adenosylhomosysteine hydrolase Sean T. Prigge and Peter K. Chiang; 9. Regulation of homocysteine metabolism James D. Finkelstein; 10. Microbial modeling of human disease: homocysteine metabolism Rowena G. Matthews and Martha L. Ludwig; 11. Folate metabolism Robert J. Cook; 12. Cobalamin-dependent remethylation Ruma V. Banerjee and Horatiu Olteanu; 13. Betaine-dependent remethylation Tim Garrow; 14. The transsulfuration pathway Warren D. Kruger; Section III. Physiology: 15. Cellular transport and tissue distribution Brian Fowler; 16. Homocysteine and the kidney John T. Brosnan; 17. Homocysteine and the nervous system Anne M. Molloy and Donald G. Weir; Section IV. Clinical Chemistry: 18. Methodologies of testing Karsten Rasmussen and Jan Möller; 19. Methionine loading Nicholas Dudman and Jonathan Silberberg; Part II. Clinical Dysfunction and Hyperhomocysteinemia; Section V. Genetic Disorders: 20. Cystathionine-ß-synthase and its deficiency Jan P. Kraus and Viktor Kozich; 21. Inborn errors of folate and cobalamin metabolism David S. Rosenblatt; 22. Polymorphisms of folate and cobalamin metabolism Rima Rozen; Section VI. Acquired Disorders: 23. Folate deficiency Ralph Carmel; 24. Cobalamin deficiency Ralph Carmel; 25. Vitamin B6 deficiency Jesse F. Gregory III; 26. Homocysteine in renal disease Margret Arnadottir and Björn Hultberg; 27. Diseases and drugs associated with hyperhomocysteinemia Henk J. Blom; 28. Lifestyle factors associated with hyperhomocysteinemia Stein Emil Vollset, Helga Refsum, Ottar Nygard and Per Ueland; Section VII. Clinical Consequences of Hyperhomocysteinemia: 29. Epidemiology: vascular and thrombotic associations Petra Verhoef and Meir Stampfer; 30. Homocysteine and coronary artery disease Killian Robinson; 31. Homocysteine and cerebrovascular disease J. David Spence and James F. Toole; 32. Peripheral arterial disease Godfried Boers; 33. Venous disease Armando D'Angelo and Chiara Beltrametti; 34. Homocysteine and hemostasis Katherine A. Hajjar; 35. Cellular mechanisms of homocysteine pathogenesis in atherosclerosis Donald W. Jacobsen; 36. Homocysteine and cardiovascular physiology Steven R. Lentz; 37. Homocysteine and human reproduction T. K. A. B. Eskes; Section VIII. Intervention and Therapy: 38. Modification of hyperhomocysteinemia John M. Scott; 39. Design of clinical trials to test the homocysteine hypothesis of vascular disease Robert Clarke; 40. What is a desirable homocysteine level? Johan B. Ubbink; Index.

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