Hormesis is defined as any circumstance in which exposure of a cell or organisim to a low dose of a substance or condition results in an adaptive stimulatory/beneficial outcome, while exposure to a high dose results in an inhibitory / detrimental outcome. When plotted on a graph the shape of the dose response curve is biphasic, the hallmark of hormesis. This groundbreaking book Hormesis: A Revolution in Biology, Toxicology and Medicine describes why and how hormesis is a fundamental feature of all living systems and is based on the evolutionary principle of selection for genetic traits that confer the ability to respond adaptively to adverse environmental conditions. Using numerous specific examples the authors explain why knowledge of hormesis is important for our health, our environment, and the future of our planet. Several chapters of the book describe emerging research findings that elucidate the molecular and cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations are described.
From environmental protection policy to medical practice, it is critical that leaders recognize and understand hormesis, and incorporate it into their decision making process. The authors propose that the prevention of major diseases, including diabetes, obesity and cradiovascular disease can be achieved using hormetic approaches. Scientists, physicians, environmental gurus and anyone interested in the science underlying biology and medicine will benefit from reading this book.
Groundbreaking coverage of an oft experienced, but poorly understood phenomenon that affects all forms of life on earth.
Explains why the principle of hormesisis important to our health, our environment, and the future of our planet.
Provides specific examples of biphasic dose responses and their importance for the fields of biology, medicine and environmental safety.
Discusses how knowledge of hormesis is being applied to research aimed understanding the organization and function of biological systems.
Illustrates how disorders such as diabetes, obesity and cardiovascular disease result from the lack of exposure to beneficial environmental stresses.
Considers the implications of the cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations.
|Publisher:||Springer-Verlag New York, LLC|
|Product dimensions:||6.10(w) x 9.25(h) x 0.02(d)|
About the Author
Mark P. Mattson, Ph.D. is Chief of the Laboratory of Neurosciences at the National Institute on Aging in Baltimore, where he leads a multi-faceted research team that applies cutting-edge technologies in research aimed at understanding molecular and cellular mechanisms of brain aging and the pathogenesis of neurodegenerative disorders. He is also a Professor in the Department of Neuroscience at Johns Hopkins University School of Medicine. He has published more than 450 original research articles and numerous review articles, and has edited 10 books in the areas of mechanisms of aging and neurodegenerative disorders. Dr. Mattson has trained more than 60 postdoctoral and predoctoral students who have contributed to his being the most highly cited neuroscientist in the world.
Edward J. Calabrese, Ph.D. is a Professor and Program Director of
Environmental Health Science, at the University of Massachusetts in Amherst.
His research focuses on environmental toxicology with an emphasis on biological factors including genetic and nutritional factors that enhance susceptibility to pollutant toxicity and the environmental implications of toxicological hormesis. Dr. Calabrese has researched extensively in the area of host factors affecting susceptibility to pollutants, and is the author of more than 300 papers in scholarly journals, as well as 24 books in the field of toxicology and environmental pollution. Dr. Calabrese has received numerous awards including, most recently, the prestigious Marie Curie Prize.
Table of Contents
Hormesis: What It Is and Why It Matters Mark P. Mattson Edward J. Calabrese 1
Hormesis: Once Marginalized, Evidence Now Supports Hormesis as the Most Fundamental Dose Response Edward J. Calabrese 15
The Fundamental Role of Hormesis in Evolution Mark P. Mattson 57
Transcriptional Mediators of Cellular Hormesis Tae Gen Son Roy G. Cutler Mark P. Mattson Simonetta Camandola 69
The Devil Is in the Dose: Complexity of Receptor Systems and Responses Wayne Chadwick Stuart Maudsley 95
Exercise-Induced Hormesis Alexis M. Stranahan Mark P. Mattson 109
Dietary Energy Intake, Hormesis, and Health Bronwen Martin Sunggoan Ji Caitlin M. White Stuart Maudsley Mark P. Mattson 123
Couch Potato: The Antithesis of Hormesis Mark P. Mattson Alexis Stranahan Bronwen Martin 139
Hormesis and Aging Suresh I.S. Rattan Dino Demirovic 153
The Hormetic Pharmacy: The Future of Natural Products and Man-Made Drugs in Disease Prevention and Treatment Edward J. Calabrese Mark P. Mattson 177