Hormesis: A Revolution in Biology, Toxicology and Medicine

Hormesis: A Revolution in Biology, Toxicology and Medicine


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Product Details

ISBN-13: 9781627038515
Publisher: Springer-Verlag New York, LLC
Publication date: 11/26/2014
Edition description: 2010
Pages: 213
Product dimensions: 6.10(w) x 9.25(h) x 0.02(d)

About the Author

Mark P. Mattson, Ph.D. is Chief of the Laboratory of Neurosciences at the National Institute on Aging in Baltimore, where he leads a multi-faceted research team that applies cutting-edge technologies in research aimed at understanding molecular and cellular mechanisms of brain aging and the pathogenesis of neurodegenerative disorders. He is also a Professor in the Department of Neuroscience at Johns Hopkins University School of Medicine. He has published more than 450 original research articles and numerous review articles, and has edited 10 books in the areas of mechanisms of aging and neurodegenerative disorders. Dr. Mattson has trained more than 60 postdoctoral and predoctoral students who have contributed to his being the most highly cited neuroscientist in the world.

Edward J. Calabrese, Ph.D. is a Professor and Program Director of
Environmental Health Science, at the University of Massachusetts in Amherst.

His research focuses on environmental toxicology with an emphasis on biological factors including genetic and nutritional factors that enhance susceptibility to pollutant toxicity and the environmental implications of toxicological hormesis. Dr. Calabrese has researched extensively in the area of host factors affecting susceptibility to pollutants, and is the author of more than 300 papers in scholarly journals, as well as 24 books in the field of toxicology and environmental pollution. Dr. Calabrese has received numerous awards including, most recently, the prestigious Marie Curie Prize.

Table of Contents

Hormesis: What It Is and Why It Matters Mark P. Mattson Edward J. Calabrese 1

Hormesis: Once Marginalized, Evidence Now Supports Hormesis as the Most Fundamental Dose Response Edward J. Calabrese 15

The Fundamental Role of Hormesis in Evolution Mark P. Mattson 57

Transcriptional Mediators of Cellular Hormesis Tae Gen Son Roy G. Cutler Mark P. Mattson Simonetta Camandola 69

The Devil Is in the Dose: Complexity of Receptor Systems and Responses Wayne Chadwick Stuart Maudsley 95

Exercise-Induced Hormesis Alexis M. Stranahan Mark P. Mattson 109

Dietary Energy Intake, Hormesis, and Health Bronwen Martin Sunggoan Ji Caitlin M. White Stuart Maudsley Mark P. Mattson 123

Couch Potato: The Antithesis of Hormesis Mark P. Mattson Alexis Stranahan Bronwen Martin 139

Hormesis and Aging Suresh I.S. Rattan Dino Demirovic 153

The Hormetic Pharmacy: The Future of Natural Products and Man-Made Drugs in Disease Prevention and Treatment Edward J. Calabrese Mark P. Mattson 177

Index 199

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