Pub. Date:
Springer New York
Hox Genes: Studies from the 20th to the 21st Century / Edition 1

Hox Genes: Studies from the 20th to the 21st Century / Edition 1

by Jean S. Deutsch


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Product Details

ISBN-13: 9781441966728
Publisher: Springer New York
Publication date: 05/27/2010
Series: Advances in Experimental Medicine and Biology , #689
Edition description: 2010
Pages: 169
Product dimensions: 6.70(w) x 10.20(h) x 0.60(d)

About the Author

JEAN S. DEUT SCH, is Emeritus Professor of Genetics and Animal Biology, Université Pierre et Marie Curie, Paris 6, Department (UMR 7622) “Biologie du Développement”. Under the supervision of Prof. P.P. Slonimski, he participated to the birth of mitochondrial genetics of the yeast Saccharomyces cerevisiae. During the ‘80s, he moved to the Institut Jacques Monod in Paris to study developmental genetics of Drosophila melanogaster, focusing on the genetics of the hormonal control of metamorphosis. In 1993, he was the first in France, together with André Adoutte, to undertake evo-devo studies, choosing the cirripedes, which have been Darwin’s favourite animals, as a model, because of their so peculiar body plan. In a second step, his team studied the developmental genetics of other arthropods, including scorpions and pycnogonids. He is author of a number of scientific publications in international journals, and of three textbooks in French on Drosophila and genetics.

Table of Contents

Section I. Mechanisms of Activity
1. Regulation of Hox Activity: Insights from Protein Motifs
Samir Merabet, Nagraj Sambrani, Jacques Pradel and Yacine Graba
The Homeodomain
The Hexapeptide Motif
Additional Hox Functional Motifs
2. Cis?Regulation in the Drosophila Bithorax Complex
Robert K. Maeda and François Karch
Genetics of the Bithorax Complex: The Model of Ed Lewis
The BX?C Encodes Only Three Genes, Ubx, abd?A and Abd?B
The Segment?Specific Functions Act as Segment/Parasegment?Specific Enhancers
Initiation and Maintenance Phase in BX?C Regulation
Initiation, Maintenance and Cell Type?Specific Elements within the Cis?Regulatory Domain
The Cis?Regulatory Regions Are Organized in Segment?Specific
Chromosomal Domains
Chromatin Boundaries Flank the Parasegment?Specific Domains
Elements Mediating Long?Distance Cis- and Trans- Regulatory Interactions
Transvection Studies
Promoter Targeting Sequences
Promoter Tethering Element
Intergenic Transcription in the BX?C
MicroRNAs in the BX?C
3. Maintenance of Hox Gene Expression Patterns
Samantha Beck, Floria Faradji, Hugh Brock and Frédérique Peronnet
Genetics of PcG and trxG Genes
PcG Proteins and their Complexes
TrxG Proteins and Their Complexes
ETP Proteins
PcG and trxG Response Elements
Recruitment of Maintenance Proteins to Maintenance Elements
Role of Maintenance Proteins in Regulation of Transcription
Epigenetic Marks
Release of PcG Silencing
Role of PcG proteins in Chromatin Replication
Role of PcG Proteins in Stem Cells
Future Research in the Field
4. Control of Vertebrate Hox Clusters by Remote and Global Cis?Acting Regulatory Sequences
François Spitz
Colinearity and Clustering of the Homeotic Genes: An Obligatory Functional Link?
Vertebrate Hox Clusters are More Clustered Than Others
Global Regulation of the Complex through Shared Mechanisms: The Retinoic Acid Connection
High?OrderStructures Over the Complex and Colinearity
Control of Vertebrate Hox Genes by Shared Internal Enhancers
The Ins and Outs of Hoxd Gene Regulation
The Role of the Flanking Regions in the Control of Vertebrate Hox Genes
Control of the HoxD Cluster through Remote Enhancers
Regulation of the HoxD Cluster and More: Global Control Regions and Regulatory Landscapes
Remote Enhancers for the Other Vertebrate Hox Clusters?
An Evolutionary Success Story and an Increasing Need for a Global Regulation
Conclusion and Outlook for Hox Gene Regulation in the 21st Century

Section II. Evolution of Hox Genes and Complexes
5. The Early Evolution of Hox Genes: A Battle of Belief?
Bernd Schierwater and Kai Kamm
The Hox System
Phylogenetic Evidence
Opposing Views
6. Evolution of Hox Complexes
David E.K. Ferrier
Origin of the ProtoHox Gene
Origin of the Hox Cluster from a ProtoHox Cluster, or Not?
Expansion and Contraction of the Number of Hox Genes in Evolution
7. The Nematode Story: Hox Gene Loss and Rapid Evolution
Aziz Aboobaker and Mark Blaxter
Introduction: Hox Gene Loss, the Third Way
The Caenorhabditis elegans Hox Cluster, an Extreme Case of Gene Loss
Tracing Hox Gene Loss through the Nematode Phylum: Mode and Tempo
Sea Squirts and Nematodes: Why Do Both Groups Lose Hox Genes
Hox Gene Loss in Flagrante
Nematode Hox Gene Function: A Story of Novelty, Conservation and Redeployment
8. Are the Deuterostome Posterior Hox Genes a Fast?Evolving Clas?
Robert Lanfear
The Distribution of the Posterior Hox genes in the Metazoa
Early Duplications of the Posterior Hox Genes
The ‘Deuterostome Posterior Flexibility’ Hypothesis
The Mechanistic Basis of Deuterostome Posterior Flexibility
Conclusion and Future Directions

Section III. Biological Function
9. Hox Genes and the Body Plans of Chelicerates and Pycnogonids
Wim G.M. Damen
Arthropods, Mandibulates vs Chelicerates
Chelicerate Hox

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