Hyperpolarized and Inert Gas MRI: Theory and Applications in Research and Medicine is the first comprehensive volume published on HP gas MRI. Since the 1990’s, when HP gas MRI was invented by Dr. Albert and his colleagues, the HP gas MRI field has grown dramatically. The technique has proven to be a useful tool for diagnosis, disease staging, and therapy evaluation for obstructive lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis.
HP gas MRI has also been developed for functional imaging of the brain and is presently being developed for molecular imaging, including molecules associated with lung cancer, breast cancer, and Alzheimer’s disease. Taking into account the ongoing growth of this field and the potential for future clinical applications, the book pulls together the most relevant and cutting-edge research available in HP gas MRI into one resource.
- Presents the most comprehensive, relevant, and accurate information on HP gas MRI
- Co-edited by the co-inventor of HP gas MRI, Dr. Albert, with chapter authors who are the leading experts in their respective sub-disciplines
- Serves as a foundation of understanding of HP gas MRI for researchers and clinicians involved in research, technology development, and clinical use with HP gas MRI
- Covers all hyperpolarized gases, including helium, the gas with which the majority of HP gas MRI has been conducted
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About the Author
Dr Albert is the Lakehead University (LU)/Thunder Bay Regional Research Institute (TBRRI) Research Chair and Professor of Chemistry at LU. He co-invented the hyperpolarized (HP) gas MRI technology, and has been an ongoing pioneer in developing and applying HP gas MRI to new applications in research and preclinical settings. Dr Albert received a Ph.D. in Physical Chemistry from the University of Stony Brook, and served as a Professor at Harvard Medical School and the University of Massachusetts Medical School prior to joining the faculty at LU/TBRRI.
Dr Albert has published over 100 peer-reviewed papers and holds a 1.0 field-weighted citation impact, an H-index of 18, and 15% of his work appears in the top 10% most cited journals worldwide. His collaboration is International with 47.4% of his work co-authored by researchers in other countries.
He is a leader in next-generation outgrowths of HP gas MRI: HP xenon functional MRI (xenon fMRI), HP xenon biosensor MR molecular imaging, and fluorine-19 lung MRI of inert fluorinated gases. For his contributions to the field of HP gas MRI, Dr Albert received a Presidential Early Career Award for Scientists and Engineers from U.S. President William Clinton in 1998.Dr Hane is a post-doctoral fellow at TBRRI. He earned a Ph.D. in Biophysics from the University of Waterloo. He has contributed numerous conference talks and poster presentations. His doctoral work examined the role of metals and aggregation inhibitors on amyloid-ß, the protein implicated in Alzheimer’s disease. The discoveries are important in understanding the very initial stages of the Alzheimer’s disease cascade.
Dr Hane has published 20 peer-reviewed papers and carries a 1.42 field-weighted citation impact, H-index of 5, with 30.8% of his work appearing in the top 10% most cited journals worldwide. 33.3% of his collaboration has been International, co-authored by researchers in other countries.
Since completing his PhD, Dr Hane trained as a post-doctoral fellow under the supervision of Dr Albert. Dr Hane is presently working on developing new applications of HP gas MRI, including molecular imaging of amyloid oligomers for early detection or Alzheimer’s disease using HP xenon biosensor MRI, in collaboration with Dr Albert at TBRRI. Dr Hane is an expert on HP gas MRI molecular probes.
Table of Contents
Chapter 1. MRI Acquisition Techniques
Chapter 2. The Physics of Hyperpolarized Gas MRI
Chapter 3. Dynamic Imaging of Lung Ventilation and Gas Flow With Hyperpolarized Gas MRI
Chapter 4. Persistence of Ventilation Defects in Asthmatics
Chapter 5. Hyperpolarized 3He Gas MRI Studies of Pulmonary Disease
Chapter 6. Pediatric Imaging and Cystic Fibrosis
Chapter 7. Hyperpolarized Gas MRI of Radiation-Induced Lung Injury
Chapter 8. Development and Application of Mouse Imaging Using Hyperpolarized Xenon
Chapter 9. Quantitative Ventilation Imaging Using Hyperpolarized Gas and Multibreath Imaging Sequences
Chapter 10. PAO2 Mapping Using HP Gas MRI
Chapter 11. Hyperpolarized Xenon-129 Dissolved-Phase Magnetic Resonance Imaging
Chapter 12. Lung Morphometry With HP Gas Diffusion MRI: From Theoretical Models to Experimental Measurements
Chapter 13. CT and MRI Gas Ventilation Imaging of the Lungs
Chapter 14. Hyperpolarized Gas MRI of the Lung in Asthma
Chapter 15. Oxygen-Enhanced MR Imaging for Lung: Basics and Clinical Applications
Chapter 16. Brain Imaging Using Hyperpolarized Xenon MRI
Chapter 17. Xenon Biosensor HyperCEST MRI
Chapter 18. Pulmonary Imaging Using 19F MRI of Inert Fluorinated Gases
Chapter 19. Surface Quadrupolar Relaxation (SQUARE) Contrast in Pulmonary MRI With Hyperpolarized 83Kr
Chapter 20. Overview & Future Directions