The thrust here is for those who want to know more than the answer to an exam question - an approach to disease diagnosis and treatment which emphasizes thoughtful consideration of alternatives, finding ones way through uncertainties and lack of knowledge. The annual seminar on which this volume is based has evolved into a forum for open discussion of puzzling questions - actually old questions in the light of new data. To me, the adventure of life is in recognizing the openendedness of all things. So you thought that a certain disease was a settled question? In medicine a "settled" question is a transient conclusion. Even the solutions to the so-called simplest problems have another side. Our aim this year was to air out concepts and conclusions about hypertension, fluid-electrolytes, and tubulopathies. The stars were Drs. Juan Rodriguez-Soriano, Alan Gruskin, and Donald Potter, along with Drs. Gustavo Gordillo, Ronald Kallen, and Antonia Novello as guest faculty. Local stars included Drs. Mary Jane Jesse, Jacques Bourgoignie, and Carlos Vaamonde. Their contributions added to those of the other faculty and registrants, coalesced into vibrant exchanges which are reproduced here for the reader's perusal.
Table of ContentsI. Fluid-Electrolytes.- Highlights: A Systematic Approach to Clinical Acid-Base Disorders Using Algorithms.- Fluid Balance in the Newborn.- Metabolic Alkalosis of Infancy.- Highlights: Evaluation of Selected Fluid and Electrolyte Disorders.- Discussion.- II. Tubulopathies and Fluid-Electrolytes.- Clearance Methodology in the Study of Tubular Handling of Water and Sodium.- Sickle Cell Nephropathy.- Hyponatremia An Approach to the Affected Child.- Renal Handling of Potassium in Chronic Renal Insufficiency.- Highlights: Cystinosis.- Discussion.- III. Hypertension.- The Hypertension Problem in Children.- The Evaluation of the Child with Hypertension.- The Renin Angiotensin System in Childhood Hypertension.- Highlights: Initial Alterations of Renal Function in Children with Acute Streptococcal Glomerulonephritis.- Disorders of Urate Metabolism in Children and Adults.- Discussion.- IV. Treatment Modalities.- Syndrome of Inappropriate Secretion of Antidiuretic Hormone.- Management of Nephrotic Edema.- Highlights: Renal Function Modifications Induced by Furosemide in Children with Post-Streptococcal Glomerulonephritis.- Pharmacotherapy of Hypertension.- Discussion.- V. Workshop.- Clinico-Pathological Correlations.- Clinical Research and the Review Process: An Introduction Antonia C. Novello.- Participants.- Author Index.