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A discussion of the epidemiology, clinical features, and differential diagnoses of idiopathic pulmonary fibrosis (IPF). Key topics include the role of polymorphonuclear leukocytes in the pathogenesis of pulmonary fibrosis, and current treatment options, including medical therapy and lung transplantation.
Table of Contents
Epidemiology of Idiopathic Pulmonary Fibrosis, David B. Coultas and Richard Hubbard; Genetics of Idiopathic Pulmonary Fibrosis and Other Variants, David A. Schwartz, Ganesh Raghu, and Momen M. Wahidi; Clinical Features and Differential Diagnosis of Idiopathic Pulmonary Fibrosis (IPF), Talmadge E. King, Jr and David Morris; Pathology of Usual Interstitial Pneumonia (UIP), William D. Travis; Non-Specific Interstitial Pneumonia Fernando Martinez, William Travis and Joseph P. Lynch; Physiology of Idiopathic Interstitial Pneumonia (Pulmonary Function and Exercise Testing), Fernando Martinez, Kevin Flaherty, Vibha Lama and Joseph P. Lynch; Radiology of Idiopathic Interstitial Fibrosis (Chest Radiographs, HRCT), David Zisman, Kevin Flaherty, Ella Kazerooni, Joseph P. Lynch and Fernando Martinez; Other Imaging Techniques for Idiopathic Interstitial Pneumonias (Radionuclide Studies, PET Scans), R.M. du Bois and Suveer Singho Bronchoalveolar; Lavage - Role in Diagnosis or Staging of Idiopathic Interstitial Fibrosis, Robert P. Baughman and Ulrich Costabel; Pulmonary Fibrosis Complicating Connective Tissue Disease, Athol Wells; Cytokine Phenotypes and the Progression of Chronic Pulmonary Fibrosis, Steven L. Kunkel; CXC Chemokines and Angiogenic Factors in the Pathogenesis of Pulmonary Fibrosis, Robert Strieter, John Belperio, and Michael Keane; Role of Polymorphonuclear Leukocytes in the Pathogenesis of Pulmonary Fibrosis, Eric White and Theodore Standiford; Integrins in Pulmonary Fibrosis, Dean Sheppard and Laura Koth; Oxidants and Antioxidants in IPF, Jurgen Behr; Fibrin Turnover in Pulmonary Fibrosis, Steven Idell; Arachidonic Acid Metabolite: Potential Mediators and Therapeutic Targets in Fibrotic Lung Disease, Marc Peters-Golden; Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Pulmonary Fibrosis, Moses Selman and Annie Pardo; Extracellular Matrix, Ronald Goldstein, David C. Rishikof and Dennis A. Ricupero; Role of Fibroblast and Myofibroblast in IPF, Sem Phan and Mehrnaz Gharaee-Kermani; Fibroblast Growth Factors (FGF), Peter Bitterman and Hyun Kim; Role of Type II Alveolar Epithelial Cells, Robert J. Mason and Josh Portnoy; Surfactant Apoproteins in the Pathogenesis of Pulmonary Fibrosis, Hiroki Takahashi; Bronchiolar Epitherlium in IPF/UIP, Marco Chilosi and Gianpietro Semenzato; Role of Viruses in the Pathogenesis of Pulmonary Fibrosis, Gary Hunninghake and Lois Geist; Current Treatment Options (Medical Therapy, Lung Transplantation), R.M. du Bois and G.P. Westall; Future Directions in Therapy, Marvin Schwarz; Future Directions in Genetic Strategies for Understanding and Treating Pulmonary Fibrosis, Ronald G. Crystal.