Imaging in Drug Discovery and Early Clinical Trials

Imaging in Drug Discovery and Early Clinical Trials

by Markus Rudin (Editor)


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Product Details

ISBN-13: 9783764377809
Publisher: Birkhäuser Basel
Publication date: 08/18/2006
Series: Progress in Drug Research , #62
Edition description: 2005
Pages: 392
Product dimensions: 6.69(w) x 9.45(h) x 0.03(d)

Table of Contents

The drug discovery process.- Imaging modalities: principles and information content.- Magnetic resonance and fluorescence based molecular imaging technologies.- Studying molecular and cellular processes in the intact organism.- Disease phenotyping: structural and functional readouts.- Evaluation of drug candidates: Efficacy readouts during lead optimization.- Risk identification and management: MRI as a research tool in toxicology studies of new chemical entities.- Pharmacokinetic studies with PET.- Imaging bio-markers predictive of disease/therapy outcome: ischemic stroke and drug development.- Clinical drug evaluation using imaging readouts: regulatory perspectives.

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