The articles in this volume represent papers delivered by invited speakers at the 6th International Symposium on the Immunobiology of Proteins and Peptides. In addition, a few of the abstracts submitted by participants were scheduled for minisymposia and some of the authors, whose presentations were judged by the Scientific Council to be of high quality, were invited to submit papers for publication in this volume. This symposium was established in 1976 for the purpose of bringing together, once every two or three years, active investigators in the forefront of contemporary immunology, to present their findings and discuss t heir significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the understanding of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptide reagents which should have enormous potential in biological, therapeutic and basic applications. This anticipated explosion has in fact since occurred and many applications of these pep tides are now being realized.
Table of ContentsStructure and Function in Recombinant HIV-1 gp120 and Speculation about the Disulfide Bonding in the gp120 Homologs of HIV-2 and SIV.- The Lentivirus Regulatory Proteins REV and REX Are Site Specific RNA Binding Proteins.- HTV-1 Neutralizing Antibody and Approaches to the Envelope Diversity Problem.- Molecular Mechanisms in the Pathogenesis of AIDS-Associated Kaposi’s Sarcoma.- Structure-Function Analysis of the HIV Glycoprotein.- Maternal Antibody Epitope Mapping in Mother-to-Child Transmission of HIV.- Immunogenicity of Synthetic Peptides Corresponding to Various Epitopes of the Human Immunodeficiency Virus Envelope Protein.- Common Sequence in HIV-1 GP41 and HLA Class II Beta Chains Can Generate Crossreactive Autoantibodies with Immunosuppressive Potential Early in the Course of HIV-1 Infection.- Isolation and Characterization of the Neutralizable Epitope of Simian Retrovirus-1 (SRV-1) and of the Cell Receptor for the Virus.- Complexes and Conjugates of cis-Pt for Immunotargeted Chemotherapy.- Radiolabeled Antibody Therapy of Human B Cell Lymphomas.- Activation of Prodrugs by Antibody-Enzyme Conjugates.- Cancer Imaging and Therapy with Radiolabeled Antibodies.- Genetic Approaches to a Vaccine for Pertussis.- Strategies for Type-Specific Glycoconjugate Vaccines of Streptococcus pneumoniae.- Immunoprophylaxis of Otitis Media.- Protection against Streptococcal Pharyngeal Colonization with Vaccines Composed of M Protein Conserved Regions.- Oral Delivery of Antigens in Live Bacterial Vectors.- Augmentation by Interleukins of the Antibody Response to a Conjugate Vaccine against Haemophilus influenzae B.- Factors Produced by Stromal Cells Involved in B-Cell Development.- Suppressor T Cells Induced in Vivo by Tolerogenic Conjugates of a Given Antigen and Monomethoxypolyethylene Glycol Downregulate Antibody Formation Also to a Second Antigen if the Latter Is Presented as a Covalent Adduct with the Former.- A Purified Saponin Acts as an Adjuvant for a T-Independent Antigen.- Modified-Live Infectious Bovine Rhinotracheitis Virus (IBRV) Vaccine Expressing Foot-and-Mouth Disease Virus (FMDV) Capsid Protein Epitopes on Surface of Hybrid Virus Particles.- Development of Non-Toxigenic Vaccine Strains of Bordetella pertussis by Gene Replacement.- Immunogenicity of Lipopolysaccharide Derived from Brucella abortus: Potential as a Carrier in Development of Vaccines for AIDS.- Antigenic Mapping of Light Chains and T Cell Receptor ? Chains.- Epitope Mapping Studies of Snake Venom Phospholipase A2 Using Monoclonal Antibodies.- Identification of Epitopes of the Receptor Binding Subunit of Cholera Toxin by Synthetic Peptide and CBIB Approaches.- Autoimmune Recognition Profile of the Alpha Chain of Human Acetylcholine Receptor in Myasthenia Gravis.- Paucity of Humoral Response in Patients to Glioma-Associated Antigen(s): Antigen Location by Immunofluorescence.- Preparation and Characterization of Antisera and of Murine Monoclonal Antibodies to Human Glioma-Associated Antigen(s).- A Peptide Antibody That Specifically Inhibits Cathepsin L.- Immunomodulating Properties of Corticotropin-Releasing Factor.