ISBN-10:
1555812465
ISBN-13:
2901555812460
Pub. Date:
04/12/2004
Publisher:
ASM Press
Immunology, Infection, and Immunity / Edition 1

Immunology, Infection, and Immunity / Edition 1

by Gerald B. Pier
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Overview

Ideally suited for upper-division and graduate-level biology students as well as medical and dental students with a good background in basic biology, biochemistry, genetics, and cell biology, this book will also appeal to scientists seeking to expand their knowledge of immunology. With a focus on the relatedness of immunology and microbiology, Immunology, Infection, and Immunity covers both the foundation concepts of immunology, among the most exciting in modern biology and medicine, and their application to the real world of diseases and health. This new text combines clear narratives of how the immune system functions, relying in many instances on supporting data from experiments. Examples and illustrations depict basic immunologic processes in conjunction with their role in infectious or other diseases in order to teach both basic and applied aspects of immunology. In addition to an emphasis on infectious diseases, the book focuses strongly on those areas where the immune system does not act when it should as well as areas where the overactivity or dysregulation of the immune system is a cause of pathology. To bring the full flavor and excitement of immunology to new students, the editors have assembled an outstanding group of contributors with expertise in multiple areas of immunology who provide the most up-to-date information in this quickly moving field.

Product Details

ISBN-13: 2901555812460
Publisher: ASM Press
Publication date: 04/12/2004
Edition description: New Edition
Pages: 718
Product dimensions: 6.00(w) x 1.25(h) x 9.00(d)

Table of Contents

Contributorsxix
Prefacexxi
About the Editorsxxiii
Section IFunction and Composition of the Immune System1
Chapter 1Overview of Immunity3
Overview of Immunology3
Innate Immunity7
Mechanisms of Adaptive Immunity11
Interactions between Acquired and Innate Immunity18
Summary26
Suggested Reading27
Chapter 2Innate Immunity29
Physical and Physiologic Barriers30
Enzymatic and Protein Effectors31
Cellular Effectors of Innate Immunity34
Innate Responses to Viral Infection41
Inflammation: Orchestrating the Innate Effectors43
Cross-Talk between the Innate and Acquired Arms of Immunity44
Summary45
Suggested Reading45
Chapter 3Cells of the Immune System47
Hematopoiesis and Generation of Cells of the Immune System47
Identification of Cells via Surface Markers49
Morphology and Function of Myeloid Cells49
Morphology and Function of Lymphoid Cells58
Major Populations and Subpopulations of Lymphocytes60
Summary64
Suggested Reading64
Chapter 4Organs and Tissues of the Immune System67
Generative Lymphoid Organs68
The Anatomy of Immune Responses70
Peripheral Lymphoid Organs76
MALT78
Cutaneous Immunity82
Summary83
Suggested Reading84
Chapter 5Complement85
Complement Proteins86
Activation of Complement87
Functions of Complement97
Regulation of Complement Activation102
Synthesis of Complement Proteins105
Disorders Associated with Defects in Synthesis of Complement Proteins106
Summary107
Suggested Reading109
Section IIAntibodies111
Chapter 6Antibodies113
Chemical Structure of Antibodies114
Classification of Antibodies134
The Immunoglobulin Superfamily141
Suggested Reading143
Chapter 7Molecular Genetics of Antibody Diversity145
Observations and Theories Predating Molecular Genetics of Immunoglobulin Genes145
Organization of the Immunoglobulin Genes148
The Mechanism of Variable-Region Gene Assembly151
Generation of Antibody Diversity162
Productive and Nonproductive Rearrangements: Allelic Exclusion170
B-Cell Differentiation171
Regulation of Immunoglobulin Expression175
An AID in the Generation of Immunoglobulin Diversity179
Summary182
Suggested Reading182
Chapter 8Antigens, Antigenicity, and Immunogenicity185
General Properties of Antigens186
Activation of T Cells and B Cells by Antigen187
Antigenicity and Immunogenicity194
Adjuvants197
Important Antigens from Infectious Agents198
Superantigens202
Mitogens204
Summary204
Suggested Reading205
Chapter 9Antibody-Antigen Interactions and Measurements of Immunologic Reactions207
The Concept of Specificity207
Deviations from Absolute Specificity210
The Physical Nature of the Antibody-Antigen Interaction213
The Law of Mass Action and Its Application to Antigen-Antibody Binding213
Types of Assays To Measure Antigen-Antibody Interactions217
Use of Antibodies To Differentiate Tissues and Cells226
Measurements of Immunity to Infection228
Measurements of Cell-Mediated Immunity230
Summary232
Suggested Reading232
Chapter 10B-Lymphocyte Activation and Antibody Production233
Interaction of Antigen and B Lymphocyte: the BCR234
Regulation of BCR Signal Transduction239
Germinal Centers and B-Cell Maturation245
Interaction of B Cells with FDCs246
Antibody Production by B Lymphocytes247
TI Antibody Response247
TD Antibody Response249
B-Lymphocyte Interaction with T Lymphocytes251
Effect of Cytokines on B-Cell Activation and Antibody Production254
Isotype Switching256
Apoptosis: the Flip Side of B-Cell Activation257
Summary258
Suggested Reading258
Section IIICellular Immunity259
Chapter 11The Major Histocompatibility Complex261
Discovery of the MHC Gene Complex261
General Arrangement of the MHC Gene Complex262
Basic Nomenclature of MHC Genes and Proteins262
Use of Inbred Mouse Strains in Experimental Immunology264
Structure of MHC Class I and Class II Proteins270
Peptide Binding by MHC Class I and Class II Proteins271
Serologic and Sequence-Based Identification of MHC Proteins and Relationship to MHC Polymorphism276
MHC Proteins with Ancillary Roles in Antigen Presentation279
MHC Class III: MHC Proteins with No Role in Antigen Presentation280
Roles of Some Nonclassical MHC Gene Products in Activation of T Cells in Response to Novel Stimuli280
MHC-Like Antigen-Presenting Molecules Encoded by Genes Located outside the MHC and Roles in Presentation of Unusual Antigens281
Summary282
Suggested Reading282
Chapter 12Antigen Processing and Presentation283
APCs284
Antigen-Processing Pathways284
Antigen Presentation by MHC Class I286
Antigen Presentation by MHC Class II291
Presentation of Nonclassical, Nonprotein Antigens to T Cells293
Summary294
Suggested Reading294
Chapter 13The T-Cell Receptor297
Isolation and Characterization of the TCR297
Structure of the TCR299
Organization of TCR Genes302
Generation of Diversity in the TCR303
Production of a Functional Receptor308
Summary313
Suggested Reading313
Chapter 14T-Cell Maturation and Activation315
T-Cell Maturation and Development in the Thymus316
Tolerance325
T-Cell Activation and Antigen Recognition334
Summary342
Suggested Reading342
Chapter 15Cellular Communication343
Interaction of Cells of the Immune System343
Soluble Mediators of Communication: Cytokines and Chemokines347
Cytokine Families358
Role of Cytokines in Other Diseases368
Summary368
Suggested Reading369
Section IVImmunologic Effector Systems and Immunity to Infection371
Chapter 16Cell-Mediated Immunity373
Fundamental Aspects of Cell-Mediated Immunity373
Initiating Cell-Mediated Immunity378
DTH Reactions379
Cell-Mediated Cytotoxicity390
CTLs390
ADCC396
Summary398
Suggested Reading398
Chapter 17Mucosal Immunity399
GALT400
Airway Immunity: BALT418
Urogenital Tract Immunity421
Damage to Mucosal Sites by the Immune Response423
Summary423
Suggested Reading423
Chapter 18Immunity to Bacterial Infections425
Bacteria and Disease425
Immune System Function and Resistance to Bacterial Infections432
The Study of How Bacteria Cause Disease: Bacterial Pathogenesis436
Initial Stage of Bacterial Infection: Colonization of Host Surfaces441
Tissue Invasion and Disease442
Bacterial Virulence Factors: How They Thwart Host Immunity445
Bioterrorism and Bacterial Pathogens448
Antigenic Targets Involved in Protective Immunity450
Summary451
Suggested Reading452
Chapter 19Immunity to Viruses453
Viruses and Disease453
Viruses and Acquired Immunity457
Structural Properties of the Virus460
Replication of the Virus462
Evasion of Host Antiviral Immune Defenses465
Summary467
Suggested Reading467
Chapter 20Immunity to Parasitic and Fungal Infections469
Protozoal Infections471
Helminthic Infections474
Immune Responses in Parasitic Infections478
Immune Effectors in Parasitic Infections486
Immune Evasion by Parasites489
Immunology of Fungal Infections492
Summary495
Suggested Reading496
Chapter 21Vaccines and Vaccination497
Early and Defining Issues in Vaccine Development498
Basic Concepts in Vaccination498
Immune Recognition of Pathogens502
Vaccine Components and Vaccination Strategies505
Bacterial Vaccines513
Viral Vaccines518
Vaccines for Fungal Infections522
Vaccines for Parasitic Diseases524
Passive Immunization527
Summary528
Suggested Reading528
Section VImmune System Dysfunction: Deficiencies529
Chapter 22Immunology and AIDS531
Etiology and Epidemiology of AIDS531
The Viral Genome537
Pathogenesis540
Immune Defects Due to HIV-1 Infection542
Immune Responses to HIV-1 Infection544
Evasion of Immune Responses by HIV-1545
Pharmacologic Therapy for HIV-1 Infection547
Potential Vaccines and Immunotherapies for HIV-1 Infection548
Summary550
Suggested Reading550
Chapter 23Clinical and Genetic Perspectives in Primary Immunodeficiency Disorders553
Basic Defects Leading to Immune Dysfunction554
Clinical Manifestations of Immunodeficiency561
Respiratory Tract Infection566
Skin Manifestations of Immune Deficiency568
Oral Manifestations of Immune Deficiency569
Viral Illnesses or Vaccine Complications of Unusual Severity570
Summary570
Suggested Reading570
Chapter 24Cancer and the Immune System573
Cancer Is a Disease of Genes575
The Immune Response to Cancer579
Mechanisms of Antitumor Immunity579
Immune Cell Types Important in Antitumor Immunity583
Tumor Surveillance Theory584
Tumor Immunotherapy585
Summary590
Suggested Reading591
Section VIImmune System Dysfunction: Overactivity593
Chapter 25Hypersensitivity595
Historical Understanding of the Concept of Hypersensitivity596
Subtypes of Allergic Responsiveness599
Summary623
Suggested Reading623
Chapter 26Autoimmunity and Disease625
Autoimmunity and Autoimmune Disease625
Targets of Autoimmune Diseases625
Pathogenesis of Autoimmune Diseases627
Animal Models of Autoimmune Diseases636
Etiology of Autoimmunity641
Therapy for Autoimmune Diseases642
Summary648
Suggested Reading648
Chapter 27Transplantation Immunology649
The Role of Major Histocompatibility Antigens versus Minor Histocompatibility Antigens in Transplantation651
Tissue Typing653
Initiation of a Graft Rejection Response654
T-Cell Activation657
Effector Mechanisms of Allograft Rejection658
Chemokines659
Graft-versus-Host Disease660
Tolerance661
Immunosuppression662
Classes of Immunosuppressive Drugs663
Summary666
Suggested Reading666
Appendix ACD Antigens667
Appendix BAntigen Names with CD Designation Equivalents675
Appendix CCytokines, Chemokines, and Their Receptors681
Appendix DCell Types an

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