This issue of Current Topics in Microbiology and Immunology records the proceedings of a Workshop on the Immunology of Sili cones held at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland, March 13 and 14, 1995. A large num ber of investigators from North America and Europe met to discuss available data on how the immune system responds to silicones and related materials. Some aspects of this field are controversial. Nonetheless, the meeting was marked by a civil and open ex change of scientific information and divergent interpretations, re flecting the traditions of scientific communication. Each invited participant was asked to submit an article sum marizing his/her presentation. Most of the papers are published as submitted, with only editorial changes to conform with the guide lines given to each contributor or revisions to clarify aspects of the paper. The papers should not be regarded as peer-reviewed publi cations. This preface will attempt to outline some of the immu nological areas of investigation relating to silicones.
Table of ContentsSilicon, Silica, Silicones: Chemistry and Degradation.- Silica, Silicon and Silicones … Unraveling the Mystery.- Silicone Degradation Reactions.- Chemical, Physical and Mechanical Analysis of Explanted Breast Implants.- Silicon and Silicone Levels in Patients with Silicone Implants.- Detection of Silicone Migration and Biodegration with NMR.- Serum Silicon Levels are Elevated in Women with Silicone Gel Implants.- Interaction of Silicones with Proteins and Tissues.- The Development of an ELISA Method for the Detection of “Antibodies” to Silicone.- The Adsorption of Proteins on a Polydimethylsiloxane Elastomer (PEP) and Their Antigenic Behavior.- Aspecific Immunoglobin Binding to Hydrophobic Surfaces.- Cytotoxicity and Membrane Damage in vitro by Inclusion Complexes Between ?-cyclodextrin and Siloxanes.- Adjuvancy of Silicones.- Induction of Type-Il Collagen Arthritis in the DA Rat Using Silicone Gel as Adjuvant.- The Adjuvancy of Silicones: Dependency on Compartmentalization.- The Adjuvant Effect of Silicone Gel and Silicone Elastomer Particles in Rats.- Silicone Gel and Octamethylcyclotetrasiloxane Potentiate Antibody Production to Bovine Serum Albumin in Mice.- Macrophages, Polyreactive and Antilipid Antibodies.- Fibrogenic and Other Biological Effects of, Silica.- Macrophages in Host Defense Mechanisms.- Structure and Function of, Natural Antibodies.- Antibodies to, Cholesterol: Biological Implications of Antibodies to Lipids.- T-Cell, NK Cell Responses to Silicones.- Silicone-lnduced, T-cell Proliferation in Mice.- Silicone-induced, Modulation of Natural Killer Cell Activity.- HLA Typing in Women with and, without Silicone Gel-filled Breast Implants.- T Cell-Mediated Immune Response to Silica in Silicone Breast Implant Patients.- Immunohistopathology and T-cell Receptor Gene Expression in Capsules Surrounding Silicone Breast Implants.- Cellular Reactions to Silicone Implants.- Macrophage-Silicone Interactions in Women with Breast Prostheses.- Microscopic Techniques and Histologic Finding in Silicone Mammary Implant Capsules and Regional Paranodal Tissues.- Autoimmune Antibodies.- Antinuclear Antibodies in Apparently Healthy Women with Breast Implants.- Silicone Binding Immunoglobulins in Human Sera. With 6 Figures.- Autoantibodies in Patients with Silicone Implants.- Clinical and Laboratory Features of Patients with Scleroderma and Silicone Implants.- Re-Evaluation of Autoantibodies and Clinical Overview of Silicone-Related Disorders. With 1 Figure.- Development of Scleroderma-like Syndrome in Tsk/+ Mice is not Enhanced by Silicone Administration.- Comparative Epitope Mapping of Antibodies to Collagen in Women with Silicone Breast Implants, Systemic Lupus Erythematosus and Rheumatoid Arthritis.- The Prevalence of Autoantibodies in Symptomatic and Asymptomatic Patients with Breast Implants and Patients with Fibromyalgia.- Monocyte/Macrophage Infiltrates in the Salivary Glands of Women with Silicone Breast Implants.- Novel Anti-Silicone Surface-associated Antigen Antibodies (anti-SSAA(x)) may help Differentiate Symptomatic Patients with Silicone Breast Implants from Patients with Classical Rheumatological Disease.- Laboratory Studies in Breast Implant Patients: ANA Positivity Gammaglobulin Levels, and Other Autoantibodies.- MGUS, Myeloma, Plasmacytoma.- IS the Risk of Multiple Myeloma Increased in Patients with Silicone Implants?.- Multiple Myeloma in Women with Silicone Breast Implants. Serum Immunoglobulin and lnterleukin-6 Studies in Women at Risk. With 3 Figures.- Silicone Gel Implants and Monoclonal Gammopathies: Three Cases of Multiple Myeloma and the Prevalence of Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance.- Monoclonal Gammopathy of Undetermined Significance.- The National Cancer Institute Silicone Implant/Multiple Myeloma Registry.- The Epidemiology of Monoclonal Gammopathy of Unknown Significance: A Review.- Plasmacytoma Development in Mice Injected with Silicone Gels. With 6 Figures.- Epidemiology.- The Association of Augmentation Mammoplasty with Connective Tissue Disease, Including Systematic Sclerosis (Scleroderma): A Meta-Analysis.- The Prevalence of Breast Implants Among Women in the United States.- Epidemiology of Autoimmune and Immunological Diseases in Association with Silicone Implants: Is There an Excess of Clinical Disease or Antibody Response in Population-based or Other “Controlled” Studies?.