Immunotoxicity Testing: Methods and Protocols / Edition 1

Immunotoxicity Testing: Methods and Protocols / Edition 1

by Rodney R. Dietert
ISBN-10:
1607614006
ISBN-13:
9781607614005
Pub. Date:
02/16/2010
Publisher:
Springer-Verlag New York, LLC
ISBN-10:
1607614006
ISBN-13:
9781607614005
Pub. Date:
02/16/2010
Publisher:
Springer-Verlag New York, LLC
Immunotoxicity Testing: Methods and Protocols / Edition 1

Immunotoxicity Testing: Methods and Protocols / Edition 1

by Rodney R. Dietert

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Overview

Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Prools, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed laboratory prools, chapters include a description of the evolution of immunotoxicity testing, a look at the importance of immunotoxicity testing for health risk reduction, and ideas concerning the future of the field. Composed in the highly successful Methods in Molecular Biology(tm) series format, most chapters contain a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips from the experts on troubleshooting and avoiding known pitfalls.

Comprehensive and innovative, Immunotoxicity Testing: Methods and Prools is a critical, one-stop reference resource for the most important and commonly used laboratory prools in immunotoxicology.


Product Details

ISBN-13: 9781607614005
Publisher: Springer-Verlag New York, LLC
Publication date: 02/16/2010
Series: Methods in Molecular Biology , #598
Edition description: 2010
Pages: 430
Product dimensions: 7.10(w) x 10.10(h) x 1.20(d)

Table of Contents

Preface v

Contributors ix

Part I Introduction

1 Immunotoxicology Testing: Past and Future Michael I. Luster G. Frank Gerberick 3

Part II Overview and Health-Risk Considerations

2 Developmental Immunotoxicity (DIT): The Why, When, and How of DIT Testing Rodney R. Dietert Jamie DeWitt 17

3 An In Vivo Tiered Approach to Test Immunosensitization by Low Molecular Weight Compounds Irene S. Ludwig Lydia M. Kwast Dani?lle Fiechter Raymond H.H. Pieters 27

4 Risk of Autoimmune Disease: Challenges for Immunotoxicity Testing Rodney R. Dietert Janice M. Dietert Jerrie Gavalchin 39

5 Markers of Inflammation Dori R. Germolec Rachel P. Frawley Ellen Evans 53

6 Evaluating Macrophages in Immunotoxicity Testing John B. Barnett Kathleen M. Brundage 75

Part III Immunotoxicity and Host Resistance Models

7 Host Resistance Assays Including Bacterial Challenge Models Florence G. Burleson Gary R. Burleson 97

8 Viral Host Resistance Studies Wendy Jo Freebern 109

9 Parasite Challenge as Host Resistance Models for Immunotoxicity Testing Robert W. Luebke 119

10 Tumor Challenges in Immunotoxicity Testing Sheung Ng Kotaro Yoshida Judith T. Zelikoff 143

Part IV Testing Protocols in Rodents and Other Laboratory Animals

11 The T-Dependent Antibody Response to Keyhole Limpet Hemocyanin in Rodents Lisa M. Plitnick Danuta J. Herzyk 159

12 The Sheep Erythrocyte T-Dependent Antibody Response (TDAR) Kimber L. White Deborah L. Musgrove Ronnetta D. Brown 173

13 The Delayed Type Hypersensitivity Assay Using Protein and Xenogeneic Cell Antigens Rodney R. Dietert Terry L. Bunn Ji-Eun Lee 185

14 The Cytotoxic T Lymphocyte Assay for Evaluating Cell-Mediated Immune Function Gary R. Burleson Florence G. Burleson Rodney R. Dietert 195

15 NK Cell Assays in Immunotoxicity Testing Qing Li 207

16 The Local Lymph Node Assay and Skin Sensitization Testing Ian Kimber Rebecca J. Dearman 221

17 Use of Contact Hypersensitivity in Immunotoxicity Testing Jacques Descotes 233

18 Evaluation of Apoptosis in Immunotoxicity Testing Mitzi Nagarkatti Sadiye Amcaoglu Rieder Dilip Vakharia Prakash S. Nagarkatti 241

19 Dendritic Cells in Immunotoxicity Testing Donghong Gao David A. Lawrence 259

20 Evaluating Cytokines in Immunotoxicity Testing Emanuela Corsini Robert V. House 283

21 Flow Cytometry in Preclinical Drug Development Patrick B. Lappin 303

22 Enhanced Histopathology Evaluation of Lymphoid Organs Susan A. Elmore 323

23 Immunotoxicity Testing in Nonhuman Primates Stephanie Grote-Wessels Werner Frings Clifford A. Smith Gerhard F. Weinbauer 341

Part V Evaluation in Humans

24 Fundamentals of Clinical Immunotoxicology Robert V. House 363

Part VI Wildlife Testing

25 In Vivo Functional Tests for Assessing Immunotoxicity in Birds Keith A. Grasman 387

Part VII In Vitro Alternatives

26 In Vitro Testing for Direct Immunotoxicity: State of the Art D.P.K. Lankveld H. Van Loveren K.A. Baken R.J. Vandebriel 401

Index 425

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