The subject of this book is the problem of infection following transplantation; it represents the principle cause of death among these patients and hence, its diagnosis,
prevention and treatment are critical.
The book covers all aspects of infection in these patients.
Itis based upon a composite case description with questions on patient management. These were addressed by a panel of experts. Each expert prepareda chapter on one or more topics.
Table of ContentsI. Introduction.- Bone Marrow Transplantation for Cancer: An Overview.- Infection in Bone Marrow Transplantation: A Model for Examining Predisposing Factors to Infection in Cancer Patients.- II. Case Presentation.- to Case Presentation.- III. Infection and Granulocytopenia.- Initial Empiric Therapy for Fever in Neutropenia.- Approach to the Patient with Prolonged Granulocytopenia.- Simplification of Empiric Therapy for the Febrile Neutropenic Oncology Patient.- Fever and Granulocytopenia: A Viewpoint from an Academic Setting.- Empiric Antimicrobial Therapy in the Community Hospital Setting for the Cancer Patient with Fever and Neutropenia: The Need for Vigilance and Attention to Detail.- Observations on the Effects of Hematopoietic Colony Stimulating Factors on the Clinical Course of Bone Marrow Transplantation.- Effect of Colony-Stimulating Factors on Granulocyte Function.- Invasive Aspergillosis: Host Defenses.- Invasive Aspergillosis: Serologic Diagnosis.- Aspergillosis in the Immunocompromised: Focus on Treatment.- Invasive Candidiasis During Granulocytopenia.- IV. Infections and Cellular Immune Dysfunction.- Infections in Cancer Patients with Suppressed Cellular Immunity.- Herpes Simplex Infections.- Treatment and Prophylaxis of Cytomegalovirus Infection After Bone Marrow Transplantation.- Varicella Zoster Infections in Bone Marrow Transplants.- Graft-Versus-Host Disease: Basic Considerations.- Graft-Versus-Host Disease: Implications.- V. Infections Related to Humoral Immune Deficiency/ Vascular Access/Transfusions.- Late Bacterial Infections in Humoral Immune Deficiency.- Hepatitis B and C: Influence of Immunosuppression.- Emergence of Gram-Positive Infections: Relationship to Indwelling Catheters and Management During Chemotherapy-Induced Aplasia.- VI. New Pathogens/Resistance/Drug Delivery.- New Pathogens in the Immunocompromised Host.- Resistant Bacterial Infections.- VII. Clinical Trials: Perspectives.- Organization of Clinical Trials: Problems, Controversies, Definitions, and Methodology Related to Infections in Neutropenic Patients.- Organization of Clinical Trials: Problems, Controversies, Definitions, Methodology.- Case Presentation with Answers to Questions.