Pub. Date:
Springer New York
Infectious Disease Informatics

Infectious Disease Informatics

by Vitali Sintchenko


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There are several reasons to be interested in infectious disease informatics. First, it is of practical significance to understand how the technology revolution has been reshaping infectious disease research and management, as rapid advances in geno- associated technologies have changed the very nature of the questions we can ask. Second, the emerging evidence has confirmed that the application of information technologies in healthcare enhances our ability to deal with infectious diseases. Finally, the implementation of electronic health records has created new and exciting opportunities for secure, reliable and ethically sound clinical decision support and biosurveillance guided by the genomics of pathogens with epidemic potential. This volume addresses the growing need for the critical overview of recent developments in microbial genomics and biomedical informatics relevant to the control of infectious diseases. This field is rapidly expanding, and attracts a wide audience of clinicians, public health professionals, biomedical researchers and computer scientists who are fascinated by the complex puzzle of infectious disease. This book takes a multidisciplinary approach with a calculated move away from the traditional health informatics topics of computerized protocols for antibiotic p- scribing and pathology testing. Instead authors invite you to explore the emerging frontiers of bioinformatics-guided pathogen profiling, the system microbiolo- enabled intelligent design of new drugs and vaccines, and new ways of real-time biosurveillance and hospital infection control. Throughout the book, references are made to different products supplied by public sources and commercial vendors, but this is not an endorsement of these products or vendors.

Product Details

ISBN-13: 9781489982957
Publisher: Springer New York
Publication date: 09/11/2014
Edition description: 2010
Pages: 434
Product dimensions: 6.10(w) x 9.25(h) x 0.04(d)

About the Author

Vitali Sintchenko (MBBS, PhD, FRCPA, FACHI) is a clinical microbiologist and informatician with the Sydney Medical School, The University of Sydney, Australia.

Table of Contents

1 Informatics for Infectious Disease Research and Control Vitali Sintchenko 1

2 Bioinformatics of Microbial Sequences Phil Giffard 27

3 Mining Databases for Microbial Gene Sequences Richard Christen 53

4 Comparative Genomics of Pathogens Elena P. Ivanova Arkadiy Kurilenko Feng Wang Russell J. Crawford 73

5 Systems Microbiology: Gaining Insights in Transcriptional Networks Riet De Smet Karen Lemmens Ana Carolina Fierro Kathleen Marchal 95

6 Host-Pathogen Systems Biology Christian V. Forst 123

7 Text Mining for Discovery of Host-Pathogen Interactions Stephen Anthony Vitali Sintchenko Enrico Coiera 149

8 A Network Approach to Understanding Pathogen Population Structure Caroline O. Buckee Sunetra Gupta 167

9 Computational Epitope Mapping Matthew N. Davies Darren R. Flower 187

10 Pangenomic Reverse Vaccinology Claudio Donati Duccio Medini Rino Rappuoli 203

11 Immunoinformatics: The Next Step in Vaccine Design Tobias Cohen Lenny Moise William Martin Anne S. De Groot 223

12 Understanding the Shared Bacterial Genome Jonathan R. Iredell Sally R. Partridge 245

13 Computational Grammars for Interrogation of Genomes Jaron Schaeffer Afra Held Guy Tsafnat 263

14 In silico Discovery of Chemotherapeutic Agents Lyn-Marie Birkholtz Peter Burger Samia Aci H?l?ne Valadi? Ana Lucia da Costa Loraine Brillet Tjaart de Beer Fourie Joubert Gordon Wells Vincent Breton Sylvaine Roy Abraham Louw Eric Mar?chal 279

15 Informatics for Healthcare Epidemiology Bala Hota 305

16 Automated, High-throughput Surveillance Systems for Public Health Ross Lazarus 323

17 Microbial Genotyping Systems for Infection Control Matthew O'Sullivan 345

18 Temporal and Spatial Clustering of Bacterial Genotypes Blanca Gallego 359

19 Infectious Disease Ontology Lindsay Grey Cowell Barry Smith 373

20 Populations, Patients, Germs and Genes: Ethics of Genomics and Informatics in Communicable Disease Control Gwendolyn L. Gilbert Michael Selgelid 397

Glossary 419

Index 425

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