Pub. Date:
Springer Netherlands
Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy / Edition 1

Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy / Edition 1

by Randall E. Harris


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In "Inflammation in the Pathogenesis of Chronic Diseases: The COX-2 Controversy", a worldwide panel of leading experts discusses the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. This volume is intended for scientists in medicine, epidemiology, pharmacology, molecular biology, and related fields. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives on the discovery and development of aspirin, ibuprofen, and compounds that selectively inhibit COX-2, and the potential for development of new compounds with better efficacy and safety in the 21st century. Specfic chapters illuminate the role of inflammatory mechanisms in the pathogenesis of arthritis, cardiovascular disease, cancer, neurodegenerative disease, diabetes mellitus, obesity, and other life-threatening and debilitating conditions. Experts in cardiovascular medicine explore the "COX-2 controversy" regarding adverse effects of some (not all) selective COX-2 inhibitors on the cardiovasculature. Recent findings suggest that cardiovascular risk associated with some COX-2 inhibitors may not be due to a class effect, but rather depends upon the molecular structure of specific compounds. Important findings are documented in cancer research showing that selective COX-2 inhibitors have powerful antineoplastic effects against major forms of cancer. A special section explores the current evidence supporting the role of COX-2 and inflammation in the development of Alzheimer’s disease and other neurodegenerative conditions and the potential benefit of compounds that modulate COX-2 and other inflammatory cytokines. The final section addresses nutritional modulation of inflammation and the chemopreventive value of anti-inflammatory nutraceutical agents.

Product Details

ISBN-13: 9781402056871
Publisher: Springer Netherlands
Publication date: 05/18/2007
Series: Subcellular Biochemistry , #42
Edition description: 2007
Pages: 324
Product dimensions: 6.10(w) x 9.25(h) x 0.03(d)

Table of Contents



I. Historical Perspectives

CHAPTER 1. Anti-inflammatory Drugs in the 21st Century

K. D. Rainsford, PhD

II. Inflammatory Mechanisms of Pathogenesis

CHAPTER 2. Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair

J. Brice Weinberg, MD, Beverley Fermor, PhD, Farshid Guilak, PhD

CHAPTER 3. obesity, inflammation, and vascular disease: The Role of the Adipose Tissue as an Endocrine Organ

Paolo Calabro’, MD, Edward T. H. Yeh, MD

Chapter 4. COX-2 and THE Inflammogenesis of Cancer

Randall E. Harris, MD, PhD

CHAPTER 5. Role of COX-2 in Inflammatory AND DEGENERATIVE Brain Diseases

Luisa Minghetti, PhD

III. Inflammation and Cardiovascular Disease: the Coxib Controversy

CHAPTER 6. Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors

William B. White, MD

CHAPTER 7. COX-2 inhibitors and Cardiovascular Risk

Daniel J. Salzberg, MD, Matthew R. Weir, MD CHAPTER 8. A BIOLOGICAL RATIONALE FOR THE CARDIOTOXIC EFFECTS OF ROFECOXIB: COMPARATIVE Analysis with other COX-2 Selective Agents and NSAIDs R. Preston Mason, PhD, Mary F. Walter, PhD, Charles A. Day, Robert F. Jacob, PhD

IV. COX-2 Blockade in Cancer Prevention and Therapy

CHAPTER 9. Cancer Chemoprevention by COX-2 Blockade: Results of Case Control Studies.

Randall E. Harris, MD, PhD, Joanne Beebe-Donk, Galal A. Alshafie, MD, PhD

CHAPTER 10. Strategies for Colon Cancer Prevention:

Combination of Chemopreventive Agents

Bandaru S. Reddy, DVM, PhD

V. Inflammation and Neurodegenerative Disease

CHAPTER 11. NSAIDs FOR THE Chemoprevention of Alzheimer’s Disease Christine A. Szekely, Ph.D., Terrence Town, Ph.D, Peter P. Zandi, Ph.D

CHAPTER 12. Inflammation in Parkinson’s disease:

causative or epiphenomenal?

Andreas Hald, PhD, Johan van Beek, PhD, and Julie Lotharius, PhD

VI. Nutrition, Inflammation and Chronic Disease


Michel de Logeril, MD


Frances C. Lau, PhD, Barbara Shukitt-Hale, PhD, James Joseph, PhD


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