Pub. Date:
VDM Verlag
Influence Of Zinc On The Normal And Ischaemic Retina

Influence Of Zinc On The Normal And Ischaemic Retina

by Marta Ugarte


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In the mammalian retina, endogenous chelatable zinc was shown to be localised mainly in the photoreceptors and retinal pigment epithelium. Zinc localisation in the photoreceptors varied in light and dark. Low (100 micromolar) levels of zinc sulphate (ZnSO4) counteracted glutamate- and
NMDA-induced lactate dehydrogenase release in rat cortical cultures; as well as the changes in
Gamma-aminobutyric acid (GABA)-immunoreactivity mediated by experimental ischaemia and NMDA in isolated rabbit retinas. However, high (500
micromolar) levels of ZnSO4 caused lactate dehydrogenase release and alterations in
GABA-immunoreactivity, and exacerbated the effects of
NMDA or ischaemia to the retina. When very low (1
micromolar) concentrations of ZnSO4 were present during ischaemia, GABA-immunoreactivity was localised to Müller cells, indicating that zinc prevents the metabolism of GABA in Müller cells in the ischaemic retina. High (500 micromolar) concentrations of ZnSO4
potentiated reactive oxygen species formation while ameliorating lipid peroxidation. When low (1 nanomol)
levels of ZnSO4 were injected into the vitreous humour of the rabbit eye the retina remained unaffected.

Product Details

ISBN-13: 9783639168693
Publisher: VDM Verlag
Publication date: 07/05/2009
Pages: 188
Product dimensions: 0.43(w) x 6.00(h) x 9.00(d)

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