Inositol Phosphate Signaling in Physiology and Disease / Edition 1 available in Paperback
A recent upsurge of research examining inositol phospholipids(IP)—membrane-bound species fundamental to cellsignaling—continues underscore the role of this pathway inboth normal and disease-associated cellular physiology. Thisvolume includes a selection of cutting-edge, multidisciplinaryreports borne out of the conference “Inositol PhospholipidSignaling in Physiology and Disease” held June 26–27,2012 at the New York Academy of Sciences in New York City. Papers include important developments investigating IP signaling inimmunology, cancer, inflammation, and metabolic disorders.
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About the Author
William G. Kerr, Empire Scholar and Murphy Family Professor of Children's Oncology, Pediatrics and Micriobiology & Immunology, SUNY Upstate Medical University.
Table of Contents
Introduction to Inositol Phospholipid Signaling in Physiologyand Disease vWilliam G. Kerr and Sandra Fernandes
Phosphoinositide 3-kinase and INPP4B in human breast cancer1Micka C. Bertucci and Christina A. Mitchell
Role of SHIP1 in cancer and mucosal inflammation 6Sandra Fernandes, Sonia Iyer, and William G. Kerr
Role of SHIP1 in bone biology 11Sonia Iyer, Bryan S. Margulies, and William G. Kerr
Achieving cancer cell death with PI3K/mTOR-targeted therapies15Sung Su Yea and David A. Fruman
Challenges in the clinical development of PI3K inhibitors19Cristian Massacesi, Emmanuelle di Tomaso, Nathalie Fretault, andSamit Hirawat
Rules of engagement: distinct functions for the four class IPI3K catalytic isoforms in immunity 24Klaus Okkenhaug
Control of T cell tolerance by phosphatase and tensin homolog27Alexandria Huynh and Laurence A. Turka
Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation30Shigenori Nagai, Yutaka Kurebayashi, and Shigeo Koyasu
Targeting phosphoinositide 3-kinase δ for thetreatment of respiratory diseases 35Srividya Sriskantharajah, Nicole Hamblin, Sally Worsley, AndrewR. Calver, Edith M. Hessel, and Augustin Amour
Phosphoinositide 3-kinase gamma in T cell biology and diseasetherapy 40Wai-Ping Fung-Leung
Inhibition of phosphoinositide 3-kinase γ attenuatesinflammation, obesity, and cardiovascular risk factors 44Matthias P. Wymann and Giovanni Solinas
Class III PI3K Vps34: essential roles in autophagy, endocytosis,and heart and liver function 48Nadia Jaber and Wei-Xing Zong
Inpp4b is a novel negative modulator of osteoclastdifferentiation and a prognostic locus for human osteoporosis52Jean Vacher