Inositol Phosphate Signaling in Physiology and Disease / Edition 1

Inositol Phosphate Signaling in Physiology and Disease / Edition 1

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Inositol Phosphate Signaling in Physiology and Disease / Edition 1

A recent upsurge of research examining inositol phospholipids(IP)—membrane-bound species fundamental to cellsignaling—continues underscore the role of this pathway inboth normal and disease-associated cellular physiology.  Thisvolume includes a selection of cutting-edge, multidisciplinaryreports borne out of the conference “Inositol PhospholipidSignaling in Physiology and Disease” held June 26–27,2012 at the New York Academy of Sciences in New York City. Papers include important developments investigating IP signaling inimmunology, cancer, inflammation, and metabolic disorders.

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Product Details

ISBN-13: 9781573318914
Publisher: Wiley
Publication date: 04/29/2013
Series: Annals of the New York Academy of Sciences Series
Pages: 252
Product dimensions: 6.80(w) x 9.80(h) x 0.20(d)

About the Author

William G. Kerr, Empire Scholar and Murphy Family Professor of Children's Oncology, Pediatrics and Micriobiology & Immunology, SUNY Upstate Medical University.

Table of Contents

Introduction to Inositol Phospholipid Signaling in Physiologyand Disease v
William G. Kerr and Sandra Fernandes

Phosphoinositide 3-kinase and INPP4B in human breast cancer1
Micka C. Bertucci and Christina A. Mitchell

Role of SHIP1 in cancer and mucosal inflammation 6
Sandra Fernandes, Sonia Iyer, and William G. Kerr

Role of SHIP1 in bone biology 11
Sonia Iyer, Bryan S. Margulies, and William G. Kerr

Achieving cancer cell death with PI3K/mTOR-targeted therapies15
Sung Su Yea and David A. Fruman

Challenges in the clinical development of PI3K inhibitors19
Cristian Massacesi, Emmanuelle di Tomaso, Nathalie Fretault, andSamit Hirawat

Rules of engagement: distinct functions for the four class IPI3K catalytic isoforms in immunity 24
Klaus Okkenhaug

Control of T cell tolerance by phosphatase and tensin homolog27
Alexandria Huynh and Laurence A. Turka

Role of PI3K/Akt and mTOR complexes in Th17 cell differentiation30
Shigenori Nagai, Yutaka Kurebayashi, and Shigeo Koyasu

Targeting phosphoinositide 3-kinase δ for thetreatment of respiratory diseases 35
Srividya Sriskantharajah, Nicole Hamblin, Sally Worsley, AndrewR. Calver, Edith M. Hessel, and Augustin Amour

Phosphoinositide 3-kinase gamma in T cell biology and diseasetherapy 40
Wai-Ping Fung-Leung

Inhibition of phosphoinositide 3-kinase γ attenuatesinflammation, obesity, and cardiovascular risk factors 44
Matthias P. Wymann and Giovanni Solinas

Class III PI3K Vps34: essential roles in autophagy, endocytosis,and heart and liver function 48
Nadia Jaber and Wei-Xing Zong

Inpp4b is a novel negative modulator of osteoclastdifferentiation and a prognostic locus for human osteoporosis52
Jean Vacher

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