Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics

Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics

by Derek LeRoith (Editor)

Paperback(2012)

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Product Details

ISBN-13: 9781461429623
Publisher: Springer US
Publication date: 10/24/2013
Series: Cancer Drug Discovery and Development
Edition description: 2012
Pages: 284
Product dimensions: 6.10(w) x 9.25(h) x 0.02(d)

Table of Contents

Preface.- Epidemiology of IGF-1 and Cancer.- Aging and Cancer: The IGF-I Connection.- Obesity, Type 2 Diabetes and Cancer.- IGF System and Breast Cancer.- The Role of Insulin-Like Growth Factor Signaling in Prostate Cancer Development and Progression.- Mouse Models of IGF-1 Deficiency.- Insulin-like Growth Factor Signaling in Pediatric Sarcomas.- Cancer Genes, Tumor Suppressors, and Regulation of IGF-1R Expression in Cancer.- Mouse Models of IGF-1R and Cancer.- Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy.- Targeting Insulin-like Growth Factor (IGF-1R) and Insulin Receptor Signaling by Tyrosine Kinase Inhibitors in Cancer.- Calories and Cancer: The Role of Insulin-like Growth Factor.- Cancer Cell Metabolism.- Overlaps between the Insulin and IGF-1R and Cancer.- Index

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