Insulin Resistance: Childhood Precursors and Adult Disease / Edition 1

Insulin Resistance: Childhood Precursors and Adult Disease / Edition 1

by Philip Scott Zeitler
Pub. Date:
Springer-Verlag New York, LLC

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Insulin Resistance: Childhood Precursors and Adult Disease / Edition 1

The prevalence of disorders related to insulin resistance has continued to increase throughout the developed and developing world. The world's population has continued to become more obese and sedentary. Of great concern in the last decade is the extension of these deleterious lifestyle patterns to the pediatric population, leading to both obesity and the appearance of insulin resistance-related disorders in youth as well as adults. Insulin Resistance: Childhood Precursors and Adult Disease presents topics related to insulin resistance and its consequences across the lifespan. In the first section of the book examining epidemiology, the contributors review controversies over the definition of metabolic syndrome in adults and children, current knowledge regarding the epidemiology of insulin resistance in the pediatric population and the contributions of the prenatal and early childhood environment to the development of insulin resistance. The Second part of the book explores pathophysiology, with reviews of the techniques used to study insulin resistance, as well as current knowledge of the molecular and physiologic mechanisms of insulin resistance, including the contributions of adipose tissue and biochemical mediators. This section concludes with discussion of the relationship between insulin resistance and cardiovascular, endothelial, liver and gonadal disorders. The final section of the book explores the impact of exercise and weight loss medications on insulin resistance. Insulin resistance is likely to be the most important public health concern in many parts of the world in coming decades. This volume provides up-to-date reviews of these areas, providing the reader with a current perspective on issues in insulin resistance as they affect patients across the lifespan. The hope for Insulin Resistance: Childhood Precursors and Adult disease is that it will spur continued interest in the topic on the part of clinicians and researc

Product Details

ISBN-13: 9781588298751
Publisher: Springer-Verlag New York, LLC
Publication date: 08/18/2008
Series: Contemporary Endocrinology Series
Edition description: 2008
Pages: 331
Sales rank: 898,251
Product dimensions: 6.30(w) x 9.10(h) x 0.80(d)

Table of Contents


The metabolic syndrome: definitions, controversies, and clinical utility. Lewis W Johnson MD, Ruth S Weinsk MD, PhD

Epidemiology of the Metabolic syndrome and related disorders in children and adolescents – Jennifer L Foltz MD, Stephen R Cook MD, MPH

Metabolic syndrome in children and adolescents worldwide – Orit Pinhas-Hamiel MD

Maternal-fetal contributors to the insulin resistance syndrome in youth – Dana Dabelea MD, PhD

Early childhood contributions to insulin resistance – David B Dunger MD, FRCP, FRCPCH, Burak Salgin, Ken K Ong MRCPCH PhD


Molecular Mechanisms of insulin resistance - Boris Draznin MD, PhD

Techniques used to assess insulin action – Michael J Pagliassotti PhD, Kyle T. Pfaffenbach MS, Tracy J. Horton

Adiposity is the enemy: body composition and insulin sensitivity – J Higgins PhD, William T Donahoo MD

Ectopic fat deposition: adiponectin and insulin resistance in obese adolescents – Anna MG Cali MD, Sonia Caprio MD

Mediators of insulin resistance - Rocio Periera MD, David Maahs MD

Insulin resistance and the pathogenesis of cardiovascular disease. – Ramzi Ajjan MRCP, MMed.Sci, PhD, Mark T Kearn FRCP, PhD, Peter T Grant FRCP, MD

Insulin Resistance and Cardiovascular disease: Cecilia C Low Wang MD

The liver and insulin resistance: the important convergence of endocrinology and hepatology – Charissa Y Chang, MD , Kerry Whitt MD, Zhenqi Liu MD, Stephen H Caldwell MD

Polycystic Ovarian Syndrome and metabolic syndrome: Marie-Helene. Pesant MD, Jean-Patrice BaillargeonMD


Effects of Exercise in Metabolic Syndrome and Diabetes: A Central Role for Insulin Sensitivity – Irene E Schauer MD, PhD, Judith.G. Regensteiner PhD, Jane EB. Reusch MD

Weight loss medications and the metabolic syndrome – Linda Buckley MD, Daniel Bessessen MD.

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