Pub. Date:
MIT Press
The Intact and Sliced Brain

The Intact and Sliced Brain

by Mircea Steriade


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Product Details

ISBN-13: 9780262194563
Publisher: MIT Press
Publication date: 09/28/2001
Series: A Bradford Book
Pages: 396
Product dimensions: 8.00(w) x 9.00(h) x 1.50(d)
Age Range: 18 Years

About the Author

Mircea Steriade is Professor of Anatomy and Physiology, Faculty of Medicine, Laval University, Quebec City.

Table of Contents

Chapter 1Changing Concepts on Localization of Brain Functions1
1.1Command Neurons, Brain Centers, and Complex Neuronal Circuits Underlying Brain Functions2
1.1.1Some Definitions2
1.1.2Sensory Functions9
1.1.3Motor Control16
1.1.4Behavioral States of Vigilance18
1.1.5Abnormal Mental Activities24
1.2From Discrete Cortical Localizations to the Concept of Unified Corticothalamic Networks27
1.2.1Early Attempts at Brain Localizations27
1.2.2Neuronal Properties Implicated in the Corticothalamic Dialogue31
1.2.3Fast Rhythms: An Example of Coherent Activities in Corticothalamic Networks35
1.3Multiple Modulatory Systems and Their Interactions42
1.3.1Generalized and Specific Activation43
1.3.2Conventional Synaptic and Diffuse (Volume) Transmission54
1.3.3Reciprocal Relations Among Brainstem, Diencephalic, and Forebrain Nuclei59
Chapter 2Evolution of Methods in Brain Studies65
2.1From Brain Transections to Slices and Cultures66
2.1.1Brain Transections, the Choice of Anesthesia, and Other Preparations67
2.1.2Slices and Cultures71
2.2Studies on Neuronal Structure74
2.2.1Some Developments of the Golgi Method75
2.2.2Anterograde and Retrograde Tracing Techniques76
2.2.3Chemical Anatomy79
2.2.4Intracellular Staining of Functionally Characterized Neurons81
2.3Recordings of Brain Electrical Activity85
2.3.1Electroencephalography, Magnetoencephalography, and Evoked Potentials85
2.3.2Extracellular Recordings92
2.3.3Intracellular Recordings97
2.4Noninvasive Imaging Methods101
Chapter 3Similar and Contrasting Results from Studies in the Intact and Sliced Brain103
3.1Seminal Findings in Brain Slices and Their Relation to Studies in the Intact Brain104
3.1.3Brainstem Cholinergic Nuclei119
3.2Dissimilar Data Obtained in the Sliced Brain and in Intact-Brain Preparations122
3.2.1Morphological Differences122
3.2.2Resting Properties and Firing Patterns of Cortical Neurons in Slices and Intact-Cortex Preparation129
3.2.3Functional Aspects of Thalamic Neurons Studied in Vivo and In Vitro153
3.2.4Normal and Pathological Oscillatory Activities in the Sliced and Intact Brain166
Chapter 4Building Blocks of Synaptic Networks Underlying Normal and Paroxysmal States191
4.1Neuronal Properties and Synaptic Networks of the Neocortex, Thalamus, and Related Subsystems191
4.1.3Rhinal Cortices and Amygdala Nuclear Complex207
4.2Emergent Functions of Normal Corticothalamic Networks: Oscillatory Properties and Short-Term Plasticity210
4.2.1Inhibitory Processes and Synchronization210
4.2.2Coalescence of Different Oscillatory Types in Corticothalamic Networks213
4.2.3Intracellular Activities of Neocortical Neurons During Natural Wake and Sleep States241
4.2.4Short-Term Plasticity Following Oscillations in the Thalamus and Neocortex252
4.3Paroxysmal States in Corticothalamic Networks271
Chapter 5Of Neurons and Consciousness291

What People are Saying About This


This book belongs on the shelf of every Neuroscientist interested in the dynamic function of the cerebral cortex, and its regulation by thalamocortical mechanisms.

Vernon B. Mountcastle, University Professor Emeritus, Department of Neuroscience, School of Medicine, Johns Hopkins University

From the Publisher

"Far in the frozen north of Quebec City there lives and works a master neurophysiologist, Mircea Steriade. This skilled experimentalist has now brought together in this monograph the results of his intensive studies, made over several decades, of the thalamocortical mechanisms controlling the excitability of the forebrain, a summary that is a major gift to all neuroscientists interested in the dynamic function of the forebrain. The evidence adduced bySteriade is taken almost exclusively from his own work, made with a variety of methods, in experiments always aimed at explaining the dynamic function of thalamus and cortex, and their interaction. The general subject of the relation between the two has been brought to a new level bySteriade's own investigations. "The book is unusual in a second way. Almost every page contains a sidebar on which the references are given, and in addition Steriade's insightful comments on the studies referred to, the scientists involved, and the historical and epistemological background of the work discussed. It is like two monographs in one! "This book belongs on the shelf of everyNeuroscientist interested in the dynamic function of the cerebral cortex, and its regulation by thalamocortical mechanisms."—Vernon B. Mountcastle, University Professor Emeritus, Department ofNeuroscience, School of Medicine, Johns Hopkins UniversityPlease note: Endorser gives permission to excerpt from quote.

Vernon B. Mountcastle

This book belongs on the shelf of every Neuroscientist interested in the dynamic function of the cerebral cortex, and its regulation by thalamocortical mechanisms.

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