ISBN-10:
0130305189
ISBN-13:
2900130305182
Pub. Date:
09/19/2001
Publisher:
Prentice Hall
Integrated Cardiopulmonary Pharmacology / Edition 1

Integrated Cardiopulmonary Pharmacology / Edition 1

by Bruce J. Colbert

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Product Details

ISBN-13: 2900130305182
Publisher: Prentice Hall
Publication date: 09/19/2001
Edition description: Older Edition
Pages: 342
Product dimensions: 6.00(w) x 1.25(h) x 9.00(d)

Table of Contents

Prefacexxiii
1General Pharmacological Principles1
Objectives1
Abbreviations2
Introduction2
Basic Terms2
Drug Development3
Herbals4
Drug Information Sources4
Interpreting Drug Information5
Routes of Administration10
Pharmacokinetics13
Pharmacodynamics17
Prescription Orders22
Common Sense Rules23
2The Metric System and Drug Dosage Calculations27
Objectives27
Abbreviations27
Introduction28
Exponential Powers of Ten28
Systems of Measurement30
Drug Dosage Calculations34
3Pharmacology of the Autonomic Nervous System43
Objectives43
Abbreviations44
Introduction44
Nervous System Divisions44
Nervous System Conduction47
ANS Drug Terminology52
4Medicated Aerosol Treatments61
Objectives61
Abbreviations61
Introduction62
Basic Concepts of Medicated Aerosols62
Aerosol Delivery Devices67
5Bronchodilators77
Objectives77
Abbreviations78
Introduction78
Airway Anatomy and Physiology78
Neurological Control of Bronchial Smooth Muscle80
Bronchodilators84
Development of the [beta] Agonists86
Anticholinergic (Parasympatholytic) Bronchodilators92
Monitoring Outcomes of Inhaled Bronchodilatory Therapy95
Xanthines96
6Mucokinetics and Surfactants101
Objectives101
Abbreviations101
Introduction102
The Mucociliary System102
Bland Aerosols106
Mucolytics109
Surface-Active Agents113
7Anti-Inflammatory and Antiasthmatic Agents123
Objectives123
Abbreviations124
Introduction124
The Inflammatory Process124
Corticosteroids129
Antiasthmatics136
Prostaglandins136
Leukotriene Modifiers137
Treating Upper Airway Congestion138
8Anti-Infective Agents143
Objectives143
Abbreviations143
Introduction144
General Principles of Anti-infective Therapy144
Classification of Antibacterial Agents150
Aerosol Anti-infective Therapy157
9Cardiac and Renal Agents161
Objectives161
Abbreviations161
Introduction162
Cardiovascular Overview162
Antiarrhythmic Agents167
Congestive Heart Failure171
Renal Pharmacology175
Shock Management177
Angina177
Myocardial Infarction179
10Blood Pressure and Antithrombotic Agents183
Objectives183
Abbreviations183
Introduction184
Blood Pressure184
Drug Categories to Treat Hypertension188
The Hemostatic System193
11Neuromuscular, Anesthetic, Sedative, and Analgesic Agents201
Objectives201
Abbreviations202
Introduction202
Nerve Transmission202
Skeletal Muscle Relaxants208
Sedative/Hypnotics/Anxiolytics208
Anesthetics210
Ventilatory Stimulants213
Analgesia214
12Therapeutic Medical Gases223
Objectives223
Abbreviations223
Introduction224
Oxygen Therapy224
Carbon Dioxide234
Helium Therapy235
Nitric Oxide Therapy236
13COPD: The Pharmacological Treatment of Asthma, Chronic Bronchitis, and Emphysema241
Objectives241
Abbreviations241
Introduction242
Asthma243
COPD253
Prevention: The Key to Treatment of COPD255
COPD Treatment Goals259
14Pharmacologic Treatment of Respiratory Infectious Disease265
Objectives265
Abbreviations266
Introduction266
Developing a Therapeutic Plan for Respiratory Infectious Diseases267
Upper Airway Infectious Diseases270
Other Upper Airway Infections276
Lower Respiratory Tract Infections277
15Pharmacology for Advanced Cardiac Life Support289
Objectives289
Abbreviations289
Introduction290
Normal Conduction and Arrhythmias290
Pharmacologic Agents for Advanced Life Support297
Pharmacology I Agents299
Calcium-Channel Blockers303
[beta]-Adrenergic Blockers305
Positive Inotropic Drugs306
References309
Drug list319
Index331

Preface

Pharmacology is often perceived as one of the more difficult subjects in a medical curriculum. There are several possible explanations. First, there are difficult concepts and terms that are inherent to this subject. Second, there is a massive amount of information, often presented in a dry and highly technical manner. Finally, once a text is printed, it is practically out of date because of all the recent breakthroughs, new drugs, and new delivery devices that have been developed before it even hits the bookstores. We took all these factors into account as we developed and pilot-tested this innovative project. So what makes this book unique and able to address these concerns?

First and foremost, this truly is an integrated project at several levels and not just a "buzz word" thrown into the title. The authors and publisher took very seriously the integrated aspect of this project and first sought the interdisciplinary perspective offered by both pharmacists and respiratory therapists. In addition, pharmacology was integrated and linked to physiology and pathology to give a total understanding and enhance connectional and relevant learning. The authors also took very seriously the concept of writing in a style that did not distance the student from the material and encouraged "learning and relating" the material versus massive memorization.

Finally, there are some things we did not take so seriously. While we were serious about the contents, relevancy, and accuracy of the material, we had fun writing, researching, and collaborating on this project. We utilized splashes of humor within this textbook, with the underlying idea that what is learned with humor isnot readily forgotten. While humor will make the learning easier, never take lightly your responsibilities as a health care professional.

SPECIAL TEXTBOOK FEATURES

Our goal is to produce a truly introductory and interactive pharmacology text that students can connect with and learn pharmacology. Several features will be incorporated into the textbook to help accomplish that goal; they include the following:

Get Connected to the Web Site: This special text feature will connect the student to a managed companion Web page with current updates, new drugs, animations, videos, audio glossary and drug pronunciation, sample tests, and references.

Learning Hints and Controversies: These special features will be contained in each chapter to ensure understanding of difficult concepts and to stimulate further thought.

Clinical Pearls: Instances of this special feature will also be interspersed throughout the chapters to connect the knowledge and show the relevancy of learning the material. In addition, numerous clinical applications will be demonstrated to give a "real world" connection.

Key Terms: Key terms will be boldfaced and included in a glossary. In addition, an audio glossary and drug name pronunciation will be provided on the Web site. Symbols, units, and abbreviation or medical terms will be defined in the chapter opener for easy reference.

Chapter Questions: Periodic "Stop and Review" problems within each chapter will help to ensure concept understanding before a student can move on and get really lost. Comprehensive questions will also be included at the end of the chapter; they will build from multiple choice and matching questions to higher-level critical thinking and case-study questions. An interactive chapter exam will also be provided on the Web site.

THE INTEGRATED WEB SITE

Further proof of the commitment to integration lies in a unique and interactive web site that fully supports the text. While the textbook can certainly stand on its own, the web site is a powerful adjunct that can greatly facilitate learning and keep both faculty and students up on the "latest and greatest" in pharmacology. One of the difficult aspects of teaching pharmacology is that by the time a textbook is produced, there is a wealth of new information, some theories are challenged, and new drugs or types of therapies are beginning to emerge. We have developed a managed companion Web site in conjunction with the textbook that will add new information for each specific chapter on a semi annual basis. For each chapter, the following "buttons" can be engaged:

Animations: Highly visual representations of complex concepts can be demonstrated and reinforced via animations. For example, protein binding is not only discussed in the text, but visual animations of protein binding and displacement can also be viewed to enhance learning.

Videos: Clinical procedures, drug preparations, and delivery devices can be viewed on quality videos. For example, various oxygen therapy delivery techniques and devices are shown, along with proper monitoring techniques.

Updates: New information that continually surfaces after the book goes into production, such as new drugs and/or treatments, will be posted semi annually to the pertinent chapter.

Glossary and Drug Pronunciation: Pharmacological terms and especially drug names are very difficult to pronounce. A very bright student can be wrongly judged in clinical owing to poor pronunciation of drug names. Therefore, each chapter will have an audio glossary and drug names section.

Extended Concepts: Additional information concerning topics within each chapter can be expanded upon within the Web site. This can allow students to further pursue knowledge in their own areas of interest.

Chapter Quiz: A sample chapter test can be taken and scored for feedback.

References and Additional Readings: These are listed per chapter. The Web site can be accessed at www.prenhall.com/colbert

DRUG COMPANION GUIDE

A separate concise pocket drug companion guide is integrated with the textbook. This guide will give further details concerning drug actions, uses, and interactions, along with specific routes and pediatric and adult dosages. In addition, more detailed pharmacokinetics, contraindications, and side effects will given, along with additional pertinent information. Removing some of this information that can easily be looked up from the textbook allows focus to be placed on "learning" pharmacologic principles and mechanisms of actions of specific drug classifications to facilitate optimal disease management. All drugs that are bolded and designated with Rx symbol are in the companion guide.

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