Integration of Mitochondrial Function

by J.J. Lemasters (Editor), C.R. Hackenbrock (Editor), R.G. Thurman (Editor), H.V. Westerhoff (Editor)

Overview

In aerobic tissues such as heart, brain, kidney, liver and brown fat, mitochon- dria account for more than 20% of cell protein and play an essential role in res- piration, ATP formation, ketogenesis, gluconeogenesis, amino acid metabolism, ureagenesis, thermogenesis and a variety of other metabolic activities. The mecha- nisms by which these activities are integrated and regulated within the overall context of cellular physiology is of much current research interest. In order to bring together scientists examining the various diverse aspects of this overall pro- blem, an International Conference on INTEGRATION OF MITOCHONDRIAL FUNC- TION was held June 4-7, 1987 at the Hanes Art Center on the campus of the Uni- versity of North Carolina at Chapel Hill. The chapters of this volume derive from presentations made at this conference. The focus of INTEGRATION OF MITOCHONDRIAL FUNCTION is on signifi- cant new experimental and theoretical advances concerning integration of mito- chondrial function at the organelle, cell, tissue and whole organism levels of organization.

Product Details

ISBN-13:	9780306429996
Publisher:	Springer US
Publication date:	02/01/1989
Edition description:	1988
Pages:	664
Product dimensions:	8.27(w) x 11.69(h) x 0.06(d)

Table of Contents

Diffusional Integration of Mihondrial Function.- Diffusional Integration of Mihondrial Function: Lateral Diffusion of Proteins in Energy Transduction.- Diffusion and Collision in Cyhrome c-Mediated Electron Transport.- Is Electron Transfer Mediated by Random Diffusion Alone?.- Role of Ubiquinone Diffusion in Mihondrial Electron Transfer.- Physical Constraints on Lateral Diffusion and Ubiquinone-Mediated Mihondrial Electron Transport.- Inhibition of Bovine Heart Mihondrial NADH — Ubiquinone Reductase by Tinopal AN, A Cationic Benzoxazole.- Topographical Changes in Cyhrome C Oxidase in the Soluble and Membrane-Bound Enzyme as Probed by Antibodies to Subunit V and the Whole Enzyme.- Multiple Forms of Cyhrome C Oxidase Observed in Heart Tissue, Myocytes, and Mihondria by Fourier Transform Infrared Spectroscopy.- Functional Importance of Mihondrial Cardiolipin in Yeast Cyhrome c Oxidase Activity.- Lateral Diffusion of Mihondrial F1F0ATP Synthase: A Random Collision Model for Proton Transfer and ATP Synthesis.- Thermodynamic Integration.- Thermodynamics and Control of Proton-Motive Free-Energy Transduction.- The Mechanism of Uncoupling of Oxidative Phosphorylation.- Upper and Lower Limits of Charge, Proton and ATP Stoichiometries of Oxidative Phosphorylation.- ATP/2e? Stoichiometries for the Coupling Sites of Mihondrial Oxidative Phosphorylation: Evaluation by Equilibrium and Non-Equilibrium Thermodynamics.- Nonequilibrium Thermodynamics and Cellular Bioenergetics.- The Near-Equilibrium Thermodynamics Approach to Living Systems.- The H+/e? Forces and Stoichiometries of the Mihondrial Respiratory Chain.- Variation of Efficiency with Free Energy Dissipation in Theoretical Models of Oxidative Phosphorylation and CyhromeOxidase.- Analysis of Mechanisms of Free Energy Coupling and Uncoupling by Inhibitor Titrations.- Flux Control and Structural Regulation.- Mechanisms Stabilizing the Protonmotive Force in Respiring Mihondria.- Regulation of Respiration and Pyruvate Dehydrogenase in Isolated Cardiac Myocytes and Hepaytes.- Control Analysis of Cellular Metabolism: Application to Gluconeogenesis in Rat-Liver Cells.- Mihondrial Volume Control.- Organization of the Mihondrial Matrix.- Competition Between Electron Transfer and ATPase in Generating Steady-State Protonmotive Force and Phosphorylation Potential.- Control of Respiration and ATP Hydrolysis in Uncoupled Mihondria.- Voltage-Dependent Channels are Present in the Inner Membrane of Mihondria.- The Kinetics of Inorganic Phosphate Uptake and Utilization by Chick Heart Mihondria.- Possible Role of Membrane-Enzyme Interactions in Activation of Pyruvate Carboxylation and Decarboxylation in Mihondria.- Duramycin Effects on Mihondrial Structure and Function.- Mihondrial Compartmentation of Branched Chain Amino Acid Catabolism: Is the Aminotransferase A Mihondrial Enzyme?.- Mihondrial Lactate Dehydrogenase.- Lithium Ion is a Competitive Inhibitor of the Na+ Selective Na+/H+ Antiporter from Mihondria.- In Situ Assessment of Mihondrial Function.- Mihondrial Membrane Potential and pH Gradient in Hypoxic Hepaytes: Characteristics of the Neahypoxic State.- Blebbing, Cytosolic Free Calcium, and Mihondrial Membrane Potential Following Toxic and Anoxic Injury in Hepaytes.- Physiological Significance of a New Adenine Nucleotide Transport Mechanism in Liver Mihondria.- Integration of Mihondrial Function with High Aerobic Glycolysis in Tumors: Role of Hexokinase Binding to the Outer Mihondrial Membrane.- Cytosolic Free Calcium and Myocardial Cell Injury.- Relationships Between Extracellular pH, Intracellular pH, and Cell Injury During ‘Chemical Hypoxia’.- Regulation of the Mihondrial ATPase In Situ in Slow and Fast Heart-Rate Hearts.- The Role of Ionized Cytosolic Calcium ([Ca2+]i) in Acute and Chronic Cell Injury.- Succinate and Oxygen Dependence of Mihondrial Function in Neonatal Hepaytes.- Cyclic Nucleotides and Mihondrial Functions at Birth.- Simultaneous Determination of Proton Concentration in Two Compartments.- Tetraphenylphosphonium Ion Distribution in Human Fibroblasts as a Function of In Vitro Aging.- Hormones and Calcium.- The Role of Calcium in the Control of Cell Function.- Hormonal Control of Ca2+-Sensitive Intramihondrial Enzymes in Mammalian Tissues.- Effect of Mihondrial Ca++ on Hepatic Aspartate Formation and Gluconeogenic Flux.- Glucagon Stimulation of Mihondrial Metabolism.- The Function of the Uncoupling Protein in the Intact Brown Fat Cell.- Hormonal Regulation of the Hepatic 2-Oxoglutarate Dehydrogenase Complex.- Ca2+-Dependent NAD(P)+-Induced Alterations in Membrane Permeability of Rat Liver Mihondria.- Integrated Mihondrial and Microsomal Regulation of Free Ca2+ in Permeabilized Insulinoma Cells.- The Estimation of the In Vivo Mihondrial Free Ca2+ Concentration.- Intercellular Integration of Energy-Linked Metabolism.- Metabolic Zonation of Carbohydrate Metabolism in the Liver.- Acinar Compartmentation of Amino Acid and Ammonia Metabolism and Its Functional Significance.- Role of Mihondria in Zone-Specific Toxicity to the Liver Lobule.- Role of Calcium in Regulation of Hepatic Oxygen Uptake.- Heterogeneity of Energy Metabolism in the Kidney.- Metabolic Key to Hypoxia Tolerance: Loss of RegulatoryLinks Between the Electron Transfer System and Glycolysis.- Glucagon Actions in Perfused Liver are Oxygen Dependent.- Microzonation of Metabolism Associated with Mihondrial Distribution in Cells.

Editorial Reviews

Proceedings of an International Conferenece on Integration of Mitochondrial Function, Chapel Hill, NC, June 1987. The focus is on significant new experimental and theoretical advances concerning integration of mitochondrial function at the organelle, cell, tissue and whole organism levels. Covers: diffusional integration of mitochondrial function, thermodynamic integration, flux control and structural regulation, in situ assessment of mitochondrial function, hormones and calcium, and intercellular integration of energy-linked metabolism. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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