A vital text for researchers and clinicians in the fields of virology and oncology alike, this book is a comprehensive guide to one of medicine’s most important tools that covers the most recent research. Important insights have been made in recent months that are challenging the accepted concept of the critical role of dsRNA in IFN induction. Recent work with genetically modified mice seems to confirm the original idea that interferon is the first cellular defense against viral infection.
Table of ContentsReflections.- 1.1 Jean Linndemann: How to chase a red herring and come up with a Smallmouth Bass. - 1.2 J. Vilcek: Interferon research before BC (before cloning).- 1.3 S. Pestka: Purification and cloning of Interferon Alpha.- Interferons and their signaling pathways.- 2.1 P. Pitha and M. Kunzi: Type I Interferon: the ever unfolding story.- 2.2 G. Uze, G. Schreiber, J. Piehler and S. Pellegrini: The receptor of the type I interferon family.- 2.3 H. Young and J. Bream: IFN: Recent Advances I Understanding Regulation of Expression, Biological Functions and Clinical Application.- 2.4 A. van Boxel-Dezaire and G. Stark: Cell Type –Specific Signaling in response to Interferon gamma.- 2.5 J. Darnell: Interferon Research; Impact on understanding transcriptional control.- Recognition of pathogens, molecular mechanism of interferon beta induction.- 3.1 M. Severa and K. Fitzgerald: TLR-mediated activation of type I IFN during antiviral immine responses:fighting the battle to win the war.- 3.2 K. Onomoto, M. Yopeneyma and T. Fujita: Regulation of Antiviral Immune Response by RIG-I family of RNA helicases.- 3.3 M.Schlee, W.Barchets, V.Hornung and G.Hartmann: Beyond double stranded RNA-type I IFN induction by 3pRNA and other viral nucleic acids.- Interferon induced genes.- 4.1 G. Sen and S. Sarkar: The Interferon-Stimulated Genes: Targets of direct signaling by interferon, double –stranded RNA and viruses.- 4.2 A.Sadler and B. Williams: Structure and Function of the Protein Kinase R.- Virus defense.- 5.1 Y-M Loo and M. Gale: Viral Regulation and Evasion of the host response.- 5.2. O.Haller and F.Weber: Pathogenic Viruses: Smart Manipulators of the Interferon System.- Role of interferon in viral infection and autoimmunity.- 6.1 E. Zuniga, B. Hahm and M. Oldstone: Type I IFN during viralinfection: multiple triggers for a multifunctiona mediator.- 6.2 S. Crow: Type I FN in Systemic Lupus Erythematosus.-