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This broadly-based reference covers all aspects of both the normal and pathological degradation of the cartilage matrix - from basic descriptions of cartilage structure to potential treatments that promote repair or regeneration of damaged cartilage.;Focusing on cartilage of the articular surfaces, this book presents all of the relevant biochemical background material; discusses in detail the building blocks of cartilage, such as collagen, aggrecan, glycoproteins and proteinases; considers both the biochemical and mechanical characteristics of cartilage breakdown; analyzes the whole organism, tissue culture and cell culture; and reviews regulatory factors, including hormones, growth factors, interleukins and retinoids.
Table of Contents
The structure and function of articular cartilage matrices, C. Anthony Poole; heterogeneity of articular chondrocytes and cartilage matrix, Margaret B. Aydelotte and Klaus E. Kuettner; growth plate structure and function, Ernst B. Hunziker; extracellular matrix of cartilage - collagen, Richard Mayne and Randolph G. Brewton; extracellular matrix of cartilage - proteoglycans, Peter J. Neame; extracellular matrix of cartilage - glycoproteins, Rose S. Fife and Kenneth D. Brandth; role of endogenous proteinases in the degradation of cartilage matrix, Hideaki Nagase and J. Frederick Woessner Jr; role of physical and mechanical agents in degrading the matrix, C.H. Evans and T.D. Brown; role of crystal deposition in matrix degradation, Herman S. Cheung and Lawrence M. Ryan; methods for evaluating mechanisms of cartilage breakdown, A. Robin Poole et al; articular cartilage organ cultures in vitro models of matrix hemeostasis, resorption or repair, Teresa I. Morales; degradation of articular cartilage in culture - regulatory factors, Mary B. Goldring; animal models of osteoarthritis, Nancy Burton-Wurster et al; cartilage degradation in animal models of inflammatory joint disease, Robert A. Greenwald; pathological cartilage degradation in human arthritides;, Robert A. Reife et al; immune responses to cartilage proteoglycans in inflammatory animal models and human diseases, Tibor T. Gland et al; pharmacological control of cartilage degradation in osteoarthritis, Gene Di Pasquale; modulation of cartilage degradation in arthritic diseases by therapeutic agents, Jean-Pierre Pelletier et al; prospects for medical intervention in cartilage repair, David Hamerman.