Life in Our Phage World

Life in Our Phage World

Hardcover

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Overview

We share the Earth with more than 10,000,000,000,000,000,000,000,000,000,000 phages. Everywhere they thrive, from well-fed guts to near-boiling acidic springs, from cryoconite holes to endolithic fissures. They travel from one microbial host to the next as virions, their genetic weapons packaged inside a protective protein shell. If you could lay all of these nanoscopic phage virions side-by-side, the line-up would stretch over 42 million light years. Through their daily shenanigans they kill or collaborate with their microbial hosts to spur microbial evolution and maintain ecosystem functioning. We have learned much about them since their discovery by Frederick Twort a century ago. They also taught us that DNA, not protein, is the hereditary material, unraveled the triplet genetic code, and offered their enzymes as indispensible tools for the molecular biology revolution. More contributions will be forthcoming since the vast majority of phages await discovery. Phage genomes harbor the world's largest cache of unexplored genetic diversity, and we now have the equipment needed to go prospecting.

Although there are field guides to birds, insects, wild flowers, even Bacteria, there was no such handbook to guide the phage explorer. Forest Rohwer decided to correct this oversight, for novice and expert alike, and thus was born Life in Our Phage World. A diverse collection of 30 phages are featured. Each phage is characterized by its distinctive traits, including details about its genome, habitat, lifestyle, global range, and close relatives. The beauty of its intricate virion is captured in a pen-and-ink portrait by artist Benjamin Darby. Each phage also stars in a carefully researched action story relating how that phage encounters, exploits, kills, or otherwise manipulates its host. These behaviors are imaginatively illustrated by fine artist Leah L. Pantéa. Eight researchers that work closely with phages also relate their experiences as inhabitants of the phage world.

Rohwer has years of first-hand experience with the phage multitudes in ecosystems ranging from coral reefs to the human lung to arctic waters. He pioneered the key metagenomic methods now widely used to catalog and characterize Earth's microbial and viral life. Despite research advances, most people, many scientists included, remain unaware of the ongoing drama in our phage world. In anticipation of 2015, the centennial of phage discovery, Forest assembled a cadre of writers, artists, scientists, and a cartographer and set them to work. The result? This alluring field guide-a feast for the imagination and a celebration of phage diversity.

Product Details

ISBN-13: 9780990494300
Publisher: Wholon
Publication date: 12/01/2014
Pages: 408
Sales rank: 707,110
Product dimensions: 8.50(w) x 11.00(h) x 1.19(d)

What People are Saying About This

Lita M. Proctor

Beautiful art, fascinating book and a wonderful historical perspective on the field. -Lita M. Proctor, Project Coordinator, NIH Human Microbiome Project

Mya Breitbart

...an excellent piece of written and visual art for newcomers to phage research and seasoned phage biologists alike. If you think phage are not relevant to your life or research, reading this is sure to change your mind! -Mya Breitbart, Associate Professor, University of South Florida

Moselio Schaechter

...spectacular, unique, trailblazing...I have never seen such a display of scholarship and artistry. You have freed scientific writing from its conventional shackles. -Moselio Schaechter, Distinguished Professor, emeritus, Tufts University, and author of Microbe and In the Company of Mushrooms

Eugene Koonin

The illustrations, the stories, and the vignettes are just delightful. It is very difficult to create such a perfect combination of science, art, and human warmth, but the authors have managed this superbly.-- Eugene Koonin, Senior Investigator, National Center for Biotechnology Information

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