Ligand Design for G Protein-coupled Receptors / Edition 1

Ligand Design for G Protein-coupled Receptors / Edition 1

ISBN-10:
3527312846
ISBN-13:
9783527312849
Pub. Date:
03/31/2006
Publisher:
Wiley

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Overview

Ligand Design for G Protein-coupled Receptors / Edition 1

G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design.
Based on recent examples from academia and the pharmaceutical industry, this book demonstrates how to apply the whole range of bioinformatics, chemoinformatics and molecular modeling tools to the rational design of novel drugs targeting GPCRs.
Essential reading for medicinal chemists and drug designers working with this largest class of drug targets in the human genome.

Product Details

ISBN-13: 9783527312849
Publisher: Wiley
Publication date: 03/31/2006
Series: Methods and Principles in Medicinal Chemistry Series , #30
Pages: 284
Product dimensions: 6.89(w) x 9.59(h) x 0.74(d)

Table of Contents

GPCRs in the human genome
GPCR Three-dimensional structures: from bovine rhodopsin to homology models
Orphan GPCRs and ligand design
GPCR databases: From genes to proteins, from proteins to ligands
Druggability of human GPCRs
Molecular Mechanisms of GPCR activation & Oligomerisation
Allosteric regulation of GPCRs
Ligand-Based rational design
Receptor-based rational design
Chemogenomics approaches to ligand design and target priorisation
GPCR targeted libraries and privileged structures

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