Liposome Technology: Volume I

by Gregoriadis

Overview

Although the role of liposomes in drug targeting has been discussed extensively in several reviews and books, there has been no comprehensive coverage of related methodology. This book constitutes the first attempt to put together all aspects of lipsome technology as applied to medical sciences. Volume I deals directly with methods for the preparation of liposomes and auxiliary techniques.

Product Details

ISBN-13:	9781315895000
Publisher:	Taylor & Francis
Publication date:	12/13/2017
Pages:	286
Product dimensions:	7.00(w) x 10.00(h) x (d)

About the Author

Gregory Gregoriadis, Ph.D., is a senior member of staff at the Medical Research Council's Clinical Research Centre, Harrow, Middlesex, England. He received his first degree in Chemistry from the University of Athens and his M.Sc. and Ph.D. in Biochemistry from McGill University. He has carried out research in as diverse fields as the metabolism of trace metals and the interaction of plasma glycoproteins with hepatic receptors. Since 1970 he has worked, published, and lectured extensively on the targeting of drugs via liposomes. Dr. Gregoriadis' interest in drug targeting is reflected in his founding in 1978 the Gordon Research Conference Series on Drug Carriers in Biology and Medicine of which he was the first Chairman and in 1981 the NATO Advanced Studies Institute Series Targeting of Drugs of which he is the Director. He has also been the editor of Drug Carriers in Biology and Medicine and the senior editor of Liposomes in Biological Systems and Targeting of Drugs.

Table of Contents

1. Physicochemical Properties of Phospholipids and Lipid-Water Systems 2. A Simple Procedure for Preparing Liposomes Capable of High Encapsulation Efficiency Under Mild Conditions 3. Preparation of Solvent Vaporization Liposomes 4. French Pressure Cell Liposomes: Preparation, Properties, and Potential 5. The Use of French Pressed Vesicles for Efficient Incorporation of Bioactive Macromolecules and as Drug Carriers In Vitro and In Vivo 6. Formation of Unilamellar Liopsomes by pH Adjustment 7. The Preparation of Variably Sized Homogenous Liposomes for Laboratory, Clinical and Industrial Use by Controlled Detergent Dialysis 8. Removal of Detergent and Solvent Traces from Liposomes 9. Polymerized Liposomes and Vesicles 10. The Preparation of Sterile Drug-Containing Liposomes 11. The Preparation of Sterile Drug-Containing Liposomes 12. Lipid Peroxidation in Liposomes 13. Size Distribution Analysis of Liposomes by Electron Microscopy 14. Hydrophobic Affinity Partition of Liposomes in Aqueous Two-Phase Systems 15. Applications of a Technique for Rapid Separation of Liposomes from Cells in Culture 16. Freezing and Thawing of Liposome Suspensions 17. Freezing of Liposomes 18. Stability Testing of Liposomes During Storage 19. Preparation of Liposomes on the Industrial Scale: Problems and Perspectives