This monograph contains papers which resulted from an international workshop on the effects of lithium on the hematopoietic and immunologic systems. The meeting was held at the John L. and Beatrice Keeshin International Biomedical Systems Planning Center of Rush University in Eagle River, Wisconsin from June 6 through June 9, 1979. The object of this conference was to bring together scientists from around the world with an interest in the effects of lithium and its potential use in human disease to bolster and stimulate the hematologic and immune systems. These topics seemed to us to be important and the time seemed right for bringing together the workers in these fields to exchange ideas and recent research results. We sought to bring together basic research scientists trying to uncover the mechanism of action of lithium in the stimulation of granulo poiesis and in its immunologic effects, together with those involved in clinical care and the use of lithium as a therapeutic tool in neoplastic and non-neoplastic disorders. This was the first use of the Keeshin Center for such a program. The sessions were conducted in a relaxed atmosphere with a good deal of give-and-take by all the participants. The editors of this book hope that it will be useful as the first volume completely devoted to these applications of lithium in these new and, as yet, incompletely developed fields.
Table of ContentsSection I: Introduction.- Lithium carbonate in medicine and psychiatry.- Biology of the lithium ion.- Release of vitamin binding proteins from granulocytes by lithium: Vitamin B12 and folate binding proteins.- Section II: Mechanisms of Lithium-Induced Granulocytosis.- The effect of lithium on release of granulocyte colony stimulating activity invitro.- The effect of lithium upon granulocyte production invitro and invivoin the mouse.- Effect of lithium on colony formation and production of colony-stimulating factor.- Myelopoietic modulation by lithium: invitro experiments on its mechanisms of action in man.- Oral lithium carbonate increases colony stimulating activity production from human mononuclear cells.- Effects of lithium chloride on human and murine marrow myeloid colony formation and colony stimulating activity.- Section III: Animal Models.- Lithium effects on granulopoiesis in mice following cytotoxic chemotherapy.- Lithium carbonate enhances granulopoiesis and attenuates cyclophosphamide-induced injury in the dog.- Lithium treatment of cyclic hematopoiesis in the gray collie.- Section IV: Lithium Attenuation of Anti-Cancer Chemotherapy.- Clinical investigation of lithium therapy in acute leukemia.- Lithium and granulocytopenia during induction therapy of acute myelogenous leukemia: update of an ongoing trial.- A placebo controlled study of a seven day course of lithium carbonate following myelotoxic chemotherapy.- The effect of lithium carbonate administration in patients with advanced small cell bronchogenic carcinoma receiving combination chemotherapy and radiotherapy.- Higher leukocyte nadirs with lithium carbonate after chemotherapy.- Prevention by using lithium carbonate of neutropenia due to antiblastics.- A seven year laboratory and clinical experience with lithium carbonate as an adjuvant to cancer chemotherapy.- Lithium attenuation of chemotherapy-induced granulocytopenia: Statistical and clinical significance?.- Section V: Lithium Therapy of Neutropenic Disorders.- In vivo and invitro effects of lithium on granulopoiesis in human neutropenic disorders.- Stimulation of granulopoiesis in vitro and invivo using lithium in children with chronic neutropenia.- Clinical experience with lithium in aplastic anemia and congenital neutropenia.- Lithium therapy of chronic neutropenia.- Lithium carbonate therapy of aplastic anemia.- Section VI: Neutrophil Function in the Presence of Lithium.- Granulocyte function in patients receiving lithium carbonate.- Inhibition of granulocyte adherence by lithium: Possible relationship to lithium-induced leukocytosis.- Effects of lithium on polymorphonuclear leukocyte chemotaxis.- Effects of lithium on neutrophil metabolism invitro and on neutrophil function during therapy.- The bactericidal defect of neutrophil function with lithium therapy.- Effect of lithium on acute myelocytic leukemia cells in tissue culture A preliminary study.- Drinking water lithium levels fail to predict for the incidences of acute or chronic granulocytic leukemia.- Section VII: Immunologic Effects of Lithium.- Adjuvant-like effects of lithium on peripheral blood mononuclear cells.- Characterization of lithium effects on two aspects of T-cell function.- Anti-suppressor cell effects of lithium invitro and invivo.- Lithium and immune function in man.