This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further,
the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.
About the Author
Table of ContentsUnderstanding the Complex Circuitry of lncRNAs at the X-inactivation Center and its
Implications in Disease Conditions.- Long Non-coding RNA ANRIL and Polycomb in
Human Cancers and Cardiovascular Disease.- Form and function of exosome associated long non-coding RNAs in cancer.- Long Non-coding RNAs in Lung Cancer.-
Pseudogene-expressed RNAs: Emerging roles in gene regulation and disease.- Functional long non-coding RNAs in vascular smooth muscle cells.- Long Non-coding RNAs as
Targets and Regulators of Nuclear Hormone Receptors.- Non-coding transcriptional landscape in human aging.- LncRNAs in stress response.- Expression
Specificity of Disease-Associated lncRNAs: towards Personalized Medicine.