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Caister Academic Press
Malaria Parasites: Genomes and Molecular Biology

Malaria Parasites: Genomes and Molecular Biology

by Andrew P. Water, Chris J. Janse


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The completion of the Plasmodium falciparum genome sequence in late 2002 heralded a new era in malaria research. The search began in earnest for new drugs and vaccines to combat malaria, a disease which afflicts up to 500 million people worldwide and is responsible for the deaths of more than one million people each year. The new genomic data is aiding a greater understanding of the living parasite and its interaction with the insect vector and human host. In this book internationally renowned experts provide up-to-date reviews of the most important aspects of post-genomic malaria research. Topics covered include: the P. falciparum genome and model parasites, bioinformatics and genome databases, microsatellite analysis, analysis of chromosome structure, cell cycle to RNA polymerase I and II mediated gene expression, role of the nuclear genome, the parasite surface and cell biology, and much more. The book is essential to all researchers working in this highly topical field and is recommended reading for scientists in other areas of biology and medicine.

Product Details

ISBN-13: 9780954246464
Publisher: Caister Academic Press
Publication date: 03/01/2004
Pages: 556
Product dimensions: 6.32(w) x 9.26(h) x 0.36(d)

Table of Contents

List of Contributorsvi
Introduction: The Plasmodium falciparum Genome Project1
Chapter 1The Genome of Plasmodium falciparum7
Chapter 2The Genome of Model Malaria Parasites, and Comparative Genomics33
Chapter 3Getting the Most out of Bioinformatics Resources65
Chapter 4Manipulating the Plasmodium Genome101
Chapter 5Toxoplasma gondii a Model Organism for the Apicomplexans?135
Chapter 6Microsatellite Markers and Population Genetics in Plasmodium falciparum167
Chapter 7Chromosome Structure and Dynamics of Plasmodium Subtelomeres187
Chapter 8Gene Expression205
Chapter 9Regulation of rRNA Transcription and Processing During the Plasmodium Life Cycle229
Chapter 10Cell Cycle Control in Plasmodium falciparum: A Genomics Perspective249
Chapter 11The Apicoplast289
Chapter 12The Surface of the Plasmodium falciparum-infected Erythrocyte339
Chapter 13Merozoite Cell Biology365
Chapter 14Sexual Development of Malaria Parasites445
Chapter 15Ookinete Cell Biology475
Chapter 16Molecular and Cellular Biology of Chloroquine Resistance in Plasmodium falciparum501
Colour PlatesA1

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