Matrix Metalloproteinases: Biology, Functions, and Clinical Implications

Matrix Metalloproteinases: Biology, Functions, and Clinical Implications


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Matrix Metalloproteinases: Biology, Functions, and Clinical Implications by Namae Oshiro, Eiko Miyagi

Matrix metalloproteinases (MMPs) are a large group of zinc- dependent extracellular endopeptidase proteinases involved in the cleavage of extracellular matrix macromolecules. MMPs play an important role in normal physiology, migration of inflammatory cells and the repair process after tissue damage. In this book, the authors present current research in the study of the biology, functions and clinical implications of matrix metalloproteinases. Topics discussed include TGF-B and MMPs as a complex regulatory loop in tumor progression; MMPs role in the pathogenesis of osteoarthritis; gelatinases in the skin; detecting MMP activity in vivo; MMPs in renal fibrosis; macrophage migration inhibitory factor as a mediator of MMP production; MMP regulation by macrolides in cardiac disorders and MMPs in neural plasticity and disease.

Product Details

ISBN-13: 9781621007890
Publisher: Nova Science Publishers, Incorporated
Publication date: 08/01/2012
Series: Rotein Biochemistry, Synthesis, Structure and Cellular Functions Series
Pages: 241
Product dimensions: 6.00(w) x 9.10(h) x 0.60(d)

Table of Contents


TGF-B and MMPs: A Complex Regulatory Loop Involved in Tumor Progression
(Miguel Quintanilla, Gael del Castillo, Jelena Kocic, Juan Francisco Santibáñez, Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, Spain, and others)

Matrix Metalloproteinase: Role in the Pathogenesis of Osteoarthritis
(Sung Won Lee, Sang Yeob Lee, Won Tae Chung, Young Hyun Yoo, Division of Rheumatology, Department of Internal Medicine, and Mitochondrial Hub Regulation Center and Department of Anatomy and Cell biology, Dong-A University College of Medicine, Busan, Republic of Korea)

Gelatinases in the Skin
(Takashi Kobayashi, Department of Dermatology, National Defense Medical College, Tokorozawa, Saitama, Japan)

Investigating Matrix Metalloproteinase Regulation in its Biological Context: Detecting MMP Activity in vivo
(Jonathan Y. Keow, Bryan D. Crawford, University of New Brunswick, Canada)

Matrix Metalloproteinases (MMPs) in Renal Fibrosis
(Guoping Zheng, Jianlin Zhang, Thian Kui Tan, Tzu-Ting Hsu, Xinrui Tian, Bo Niu, David C.H. Harris, Centre for Transplantation and Renal Research, Westmead Millennium Institute, The University of Sydney, Australia, and others)

Macrophage Migration Inhibitory Factor: A Mediator of Matrix Metalloproteinase Production
(Tadamichi Shimizu, Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan)

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