International experts evaluate mechanisms of chemically induced cell injury and cell death and their implications for human health. Among the wide variety of topics explored are the role of metabolism in mediating toxicity, molecular mechanisms of cell injury/cell death, approaches for estimating human exposure to toxic chemicals, and the known roles of toxic chemicals in human target organ toxicity. The discussions are intended to provide an overview of the most recent work in this area, to define and discuss research priorities in this field, and to indicate directions for future research.
Table of Contents
Partial table of contents:
Role of Cosubstrates in Pharmacokinetics and Toxicology (C. D. Klaassen, et al.).
Free-radical Metabolite Formation by Mammalian Peroxidases (R. P. Mason).
Perturbation of Thiol and Calcium Homeostasis in Cell Injury (P. Nicotera & S. Orrenius).
Mechanisms of Cell Injury in the Kidney: The Role of Calcium (B. F. Trump & I. K.
Cell Injury and Repair in the Lung (H. P. Witschi).
Human Exposure Monitoring for Environmental Pollutants (H. W. de Koning).
Early Biological Indicators of Chemical Exposure and Their Significance for Disease (R. D. Kimbrough).
Factors Influencing Biological Responses to Chemicals (K. R. Mahaffey).
The Role of Chemical Exposure in Irreversible Renal Injury in Humans ( R. P.
Wedeen & M. E.
De Broe) Index