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Basic Books
Mechanisms of Lymphocyte Activation and Immune Regulation

Mechanisms of Lymphocyte Activation and Immune Regulation

by S. Gupta


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Mechanisms of Lymphocyte Activation and Immune Regulation

The ac ti vati on of Iymphocytes by physiologie ligands has become a central area of study for immunologists. Furthermore, Iymphocytes offer many advantages for the study of general aspects of receptor-mediated cellular activation. For these reasons, research on the cellular and molecular aspects of the activation of Iymphocytes by antigens, antigen analogues, Iymphokines and other growth factors has expanded enormously in the last several years. Aseries of conferences, "The International Conferences on Lymphocyte Activation", has been initiated to meet the growing need for a forum for the discussion of the topics that are included within the area of Iymphocyte activation. This volume represents the proceedings of the Second International Conference on Lymphocyte Activation and Immune Regulation, held on February 18-20, 1988 at Newport Beach, California. The proceedings comprise four major sections. The first deals with the T cell receptors and T cell activation. It includes a model for the T cell receptor interaction with a complex of MHC plus antigen, structure of y c'i T cell receptor and their distinct isotypic forms, the role of zeta chain in the expression and structure of T cell receptors and its role in transmembrane signalling. The use of somatic cell mutants in the study of signal transduction function of the T cell antigen receptors and the early and late steps of signal transduction via a / ß T cell antigen receptors are discussed.

Product Details

ISBN-13: 9780306432507
Publisher: Basic Books
Publication date: 01/01/1989
Series: Advances in Experimental Medicine and Biology Series , #25
Pages: 150

Table of Contents

A Model for T Cell Receptor and MHC/Peptide Interaction.- Human T Cell Receptor ? ? Structure.- The Role of the Zeta Chain in the Expression, Structure and Function of the T Cell Receptor.- Use of Somatic Cell Mutants to Study the Signal Transduction Function of the T Cell Antigen Receptor.- Changes in Early and Late Steps of T Cell Activation by WT 31 MoAb.- Interleukin-I Induced T-Lymphocyte Proliferation and its Relation to IL-1 Receptors.- Structure and Regulation of the Human IL-2 Receptor.- Structure-Function Relationships for High and Low Affinity Interleukin 2 Receptors.- Cellular and Molecular Requirements for B Lymphopoiesis.- Transcriptional Regulation of Immunoglobulin Heavy Chain and T-Cell Receptor Beta Chain Genes.- Precursor B Lymphocytes—Specific Monoclonal Antibodies and Genes.- G-Protein Regulation of Polyphosphoinositide Breakdown in B Cells.- Signal Transduction Via the B Cell Antigen Receptor: Involvement of a G Protein and Regulation of Signaling.- Voltage-Sensitive Ion Channels in Human B Lymphocytes.- Interleukins 4 and 5: Mechanisms of Actions.- Normal and Abnormal Regulation of Human B Cell Differentiation by a New Cytokine, BSF2/IL-6.- Alternative cytokines in the immunoregulation of the human B cell cycle.

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