This book presents a series of chapters by prominent researchers in the field of microbial immunity detailing some of the recent advances in this field and correlating the significance of the results with important concepts in host protection and vaccination. Recent advances in the field of microbial immunology have resulted in increased understanding of basic concepts involved in immune cell activation and regulation. This book provides a concise overview of some of the most significant advances that have increased our understanding of how various components of the immune system protect against a very diverse array of pathogens. This volume is written primarily for immunologists, microbiologists, and vaccine researchers. However, it is also appropriate for and should be very useful to students and medical interns interested in these fields. This book examines the molecular determinants of immunity against specific pathogens and how these effector mechanisms are regulated by innate and adaptive immune responses. The text is clearly written and the figures and tables are of sufficient number and quality to effectively highlight the text of each chapter. The editors are prominent immunologists and have done an outstanding job of selecting a broad range of topics and research by contributors to the field of microbial immunity. This important book provides a very useful overview of recent research in the field of microbial immunity for both students and established researchers.
Comprises 23 contributions divided into sections on: innate defense mechanisms; effector choice, regulation of host resistance to intracellular pathogens; immunopathogenesis of HIV-1 infection; and new approaches to vaccine development. Representative topics include activating and inhibitory NK cell receptors, genetic control of the T cell response to Leishmania major infection, early cytokine responses to viral infections and their roles in shaping endogenous cellular immunity, HIV transmission and immune protection at mucosal surfaces, and DNA vaccines. Of interest primarily to researchers in immunology, microbiology, and vaccine development. Annotation c. by Book News, Inc., Portland, Or.