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Mechanisms of Synaptic Transmission: Bridging the Gaps (1890-1990)

Mechanisms of Synaptic Transmission: Bridging the Gaps (1890-1990)

by Joseph D. Robinson

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Synaptic transmission plays a central role in the nervous system as the mechanism that allows for chemical and electrical communication between cells and thus connects discrete elements into the functioning whole. This is a broad account of anatomical, biochemical, embryological, medical, pathological, pharmacological, and physiological studies on synaptic transmission during the hundred years beginning in 1890. During this century, the process of synaptic transmission came to be recognized not only as the most fundamental neurophysiological process, but also as a seat of pathological changes, and as the predominant site of action for drugs used to treat a wide range of psychiatric and neurological disorders. At the same time, research from these various disciplines was transformed into a new and unifying field, neuroscience. The course of these investigations reveals ingenious experiments, powerful new techniques, and imaginative insights. The author describes broadly who did what, when, where, and how (and, in cases where it is apparent, why) and uses experimental results and interpretations to display the evolutionary course to our current understanding of how nerve cells communicate: the basic principle of neural functioning. The book will be of interest to basic and clinical neuroscientists, pharmacologists, and physiologists, to historians and philosophers of the life sciences and medicine, and to their respective students.

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Product Details

ISBN-13: 9780198031451
Publisher: Oxford University Press
Publication date: 05/17/2001
Sold by: Barnes & Noble
Format: NOOK Book
File size: 5 MB

Table of Contents

1. Beginnings: Cajal and the Neuron Theory (1889-1909)
2. Beginnings: Sherrington and the Synapse (1890-1913)
3. Chemical Transmission at Synapses (1895-1945)
4. Chemical Transmission at Synapses (1945-1965)
5. Identifying Neurotransmitters: (1946-1976)
6. Characterizing Receptors (1905-1983)
7. Second Messengers (1951-1990)
8. Receptor Structures and Receptor Families (1983-1990)
9. Synthesis, Storage, Transport, and Metabolic Degradation of Neurotransmitters
10. Neurotransmitter Release
11. Formation of Specific Synapses
12. Learning
13. Diseases and Therapies
14. Epilogue

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